Department of Chemistry, Atlanta, GA, USA.
Chem Soc Rev. 2009 Nov;38(11):3072-81. doi: 10.1039/b816701j. Epub 2009 Apr 3.
In this tutorial review, the rhodium(II)-catalyzed domino reactions of alpha-diazo carbonyl compounds are summarized. The article will emphasize some of the more recent synthetic applications of the rhodium carbenoid cyclization/cycloaddition domino cascade for alkaloid synthesis. The many structurally diverse and highly successful examples of both oxa and azapolycyclic ring formation cited in this tutorial review clearly demonstrate that the domino cyclization/cycloaddition cascade of metallo carbenoids has evolved as an important strategy for the synthesis of nitrogen containing natural products.
在本教程综述中，总结了铑（II）催化的α-重氮羰基化合物的串联反应。本文将重点介绍铑卡宾环化/加成串联多米诺级联反应在生物碱合成中的一些最新的合成应用。本教程综述中引用的许多结构多样且非常成功的氧杂和氮杂多环环形成的例子清楚地表明，金属卡宾的串联环化/加成级联反应已发展成为含氮天然产物合成的重要策略。
