Wang Kuo, Zhang Yue, Cai Lu-Yu, Song Xiu-Qing, Wang Chen, Zhang Jia-Rui, Pan Yi-Fan, Zhao Hong-Wu
College of Life Science and Bio-Engineering, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China.
Molecules. 2023 Oct 10;28(20):7021. doi: 10.3390/molecules28207021.
Under the catalysis of Rh(OAc) (10 mol%) and binapbisphosphine ligand (±)- (20 mol%) in DCE at 80 °C, the cascade cyclization of diazoimides with alkylidenepyrazolones underwent stereoselectively (dr > 20:1), affording pyrazole-fused oxa-bridged oxazocines in reasonable chemical yields. The chemical structure and relative configuration of title products were firmly identified by X-ray diffraction analysis.
在80℃下，于二氯乙烷中，在Rh(OAc)（10摩尔%）和联萘双膦配体(±)-（20摩尔%）的催化下，重氮酰亚胺与亚烷基吡唑啉酮的串联环化反应立体选择性地进行（非对映体过量比>20:1），以合理的化学产率得到吡唑稠合的氧桥连恶唑并环辛烷。通过X射线衍射分析确定了标题产物的化学结构和相对构型。
