Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
Pituitary. 2010 Jun;13(2):111-4. doi: 10.1007/s11102-009-0204-0.
Traumatic brain injury (TBI) has been recently recognized as a leading cause of pituitary dysfunction. Current data clearly demonstrated that sports related head trauma due to boxing, kickboxing, and soccer might results in pituitary hormone deficiencies, isolated growth hormone (GH) deficiency in particular. In the present report physiologic dose GH replacement therapy (GHRT) was performed in two GH deficient retired amateur boxers for the first time. The boxers received recombinant GH for 6 months. After 6 months of GHRT there were substantial improvements, but not complete normalization, in the body composition parameters, lipid profiles and quality of life scores in both boxers. These preliminary results suggest that GHRT may have beneficial effects in retired boxers with severe isolated GH deficiency due to sports related head trauma. But more data with higher number of boxers and longer GHRT duration are warranted.
创伤性脑损伤（TBI）最近被认为是垂体功能障碍的主要原因。目前的数据清楚地表明，由于拳击、跆拳道和足球等运动导致的头部创伤可能导致垂体激素缺乏，特别是孤立性生长激素（GH）缺乏。在本报告中，我们首次对两名患有 GH 缺乏症的退役业余拳击手进行了生理剂量的 GH 替代治疗（GHRT）。拳击手接受了重组 GH 治疗 6 个月。在 GHRT 治疗 6 个月后，两名拳击手的身体成分参数、血脂谱和生活质量评分都有了显著改善，但并未完全正常化。这些初步结果表明，GHRT 可能对因运动相关头部创伤导致严重孤立性 GH 缺乏的退役拳击手有有益的影响。但需要更多的、数据更多的、持续时间更长的 GHRT 来证实。
