Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
Clin Endocrinol (Oxf). 2013 May;78(5):730-7. doi: 10.1111/cen.12037.
It has been recently reported that boxing and kickboxing may cause pituitary dysfunction, GH deficiency in particular. The strong link between poor cognitive performance and GH deficiency due to causes other than head trauma and the improvement of cognitive function after GH replacement therapy have been previously shown. P300 auditory event-related potential (ERP) measure is widely used to evaluate cognitive performance. In this study, we investigated the relation between the GH-IGF-I axis and cognitive performance in boxers and kickboxers.
Forty-one actively competing or retired male boxers (n: 27) and kickboxers (n: 14) with a mean age of 29·04 ± 9·30 year and 14 age- and education-matched healthy male controls were included in the study. For neuropsychological tests, the mini-mental state examination (MMSE) and Quality of Life Assessment of GH Deficiency in Adults (QoL-AGHDA) questionnaires were administered. Moreover, cognitive performance was evaluated according to P300 ERPs.
Nine of 41 (21·9%) athletes had GH deficiency. P300 amplitudes were lower at all electrode sites in the GH-deficient group than in controls, and the differences were statistically significant at Fz and Oz electrode sites (P < 0·05). When GH-deficient athletes were compared with GH-sufficient athletes, the P300 amplitudes were lower at all electrode sites in the GH-deficient group; these differences were statistically significant at Fz, Pz and Cz electrode sites (P < 0·05). In all athletes, there were significant negative correlations between IGF-I levels vs P300 latencies, and there were significant positive correlations between IGF-I levels vs P300 amplitudes (P < 0·05).
This study provides the first electrophysiological evidence for the close relation between the P300 ERPs and the GH-IGF-I axis in boxers and kickboxers.
最近有报道称，拳击和踢拳可能导致垂体功能障碍，特别是生长激素缺乏。先前已经表明，除头部创伤以外的其他原因导致的生长激素缺乏与认知功能差之间存在很强的联系，并且生长激素替代治疗后认知功能得到改善。听觉事件相关电位（ERP）测量 P300 广泛用于评估认知功能。在这项研究中，我们调查了拳击手和踢拳手的 GH-IGF-I 轴与认知功能之间的关系。
本研究纳入了 41 名年龄在 29·04±9·30 岁的现役或退役男性拳击手（n=27）和踢拳手（n=14）以及 14 名年龄和教育程度匹配的健康男性对照者。对于神经心理学测试，使用简易精神状态检查（MMSE）和成人 GH 缺乏生活质量评估问卷（QoL-AGHDA）进行测试。此外，还根据 P300 ERP 评估认知功能。
41 名运动员中有 9 名（21.9%）患有生长激素缺乏症。GH 缺乏组在所有电极部位的 P300 波幅均低于对照组，并且在 Fz 和 Oz 电极部位的差异具有统计学意义（P<0·05）。当将 GH 缺乏的运动员与 GH 充足的运动员进行比较时，GH 缺乏组在所有电极部位的 P300 波幅均较低，在 Fz、Pz 和 Cz 电极部位的差异具有统计学意义（P<0·05）。在所有运动员中，IGF-I 水平与 P300 潜伏期之间呈显著负相关，IGF-I 水平与 P300 波幅之间呈显著正相关（P<0·05）。
这项研究提供了第一个电生理学证据，表明拳击手和踢拳手的 P300 ERP 与 GH-IGF-I 轴之间存在密切关系。
