Nakamura M, Matsui H, Murayama S Yamagata, Matsumoto T, Yamada H, Takahashi S, Tsuchimoto K
Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Inflammopharmacology. 2007 Jun;15(3):115-8. doi: 10.1007/s10787-007-1549-5.
Helicobacter heilmannii (Hh) has been clinically reported to have some relation to gastric low grade MALT lymphoma. Recently, we have formed the gastric MALT lymphoma in C57BL/6 mice.
C57BL/6 mice infected with Hh from cynomolgus monkey for more than 6 months were used. The macroscopic, immunohistochemical and electron microscopic observation was performed
MALT lymphoma was formed in almost 100% of the infected mice. Increased VEGF-A and Flt-3 immunoreactivity was recognized.
Hh was shown to be related to the formation of MALT lymphoma and VEGF is suggested to play a role in this lymphoma.
临床报告显示，海氏螺杆菌（Hh）与胃低度黏膜相关淋巴组织淋巴瘤有一定关系。最近，我们在C57BL/6小鼠中诱导出了胃黏膜相关淋巴组织淋巴瘤。
使用感染食蟹猴来源的Hh超过6个月的C57BL/6小鼠。进行了大体、免疫组织化学和电子显微镜观察。
几乎100%的感染小鼠形成了黏膜相关淋巴组织淋巴瘤。观察到血管内皮生长因子A（VEGF-A）和Flt-3免疫反应性增加。
结果表明Hh与黏膜相关淋巴组织淋巴瘤的形成有关，并且提示VEGF在该淋巴瘤中发挥作用。
