Morgner A, Lehn N, Andersen L P, Thiede C, Bennedsen M, Trebesius K, Neubauer B, Neubauer A, Stolte M, Bayerdörffer E
Medical Department I, Technical University, Dresden, Germany.
Gastroenterology. 2000 May;118(5):821-8. doi: 10.1016/s0016-5085(00)70167-3.
BACKGROUND & AIMS: Cure of Helicobacter pylori infection may lead to complete remission of associated low-grade mucosa-associated lymphoid tissue (MALT) lymphoma in stage EI. This study investigated whether Helicobacter heilmannii infection-associated primary gastric MALT lymphoma will regress after cure of the infection.
H. heilmannii-induced gastritis was diagnosed histologically, by a new specific immunoglobulin G enzyme-linked immunosorbent assay, and with 16S ribosomal RNA amplification and sequencing in 5 consecutive patients with primary gastric MALT lymphoma clinical stage EI. Patients received 40 mg omeprazole and 750 mg amoxicillin 3 times per day for 14 days. Polymerase chain reaction (PCR) was used to detect rearrangement of immunoglobulin heavy-chain genes before treatment and during follow-up.
Five patients (3 men, 2 women; mean age, 65 years; range, 42-79 years) were studied. H. pylori was not detected by culture, histology, serology, or PCR. Treatment resulted in the cure of H. heilmannii infection in each case and complete histological and endoscopic remission of the tumors. Three of 5 patients showed monoclonal B cells before treatment, 2 of whom remained PCR positive. Within a median follow-up period of 24 months, no relapse of the lymphoma or reinfection with H. heilmannii occurred.
These data suggest that gastric MALT lymphoma may arise in patients with H. heilmannii infection. Cure of this infection may lead to complete remission of the MALT lymphoma.
幽门螺杆菌感染的治愈可能导致EI期相关的低度黏膜相关淋巴组织（MALT）淋巴瘤完全缓解。本研究调查了海尔曼螺杆菌感染相关的原发性胃MALT淋巴瘤在感染治愈后是否会消退。
通过组织学检查、一种新的特异性免疫球蛋白G酶联免疫吸附测定以及对5例连续的原发性胃MALT淋巴瘤临床EI期患者进行16S核糖体RNA扩增和测序，诊断海尔曼螺杆菌引起的胃炎。患者接受每日3次、每次40mg奥美拉唑和750mg阿莫西林治疗，共14天。采用聚合酶链反应（PCR）在治疗前和随访期间检测免疫球蛋白重链基因的重排。
研究了5例患者（3例男性，2例女性；平均年龄65岁；范围42 - 79岁）。通过培养、组织学、血清学或PCR均未检测到幽门螺杆菌。治疗使每例患者的海尔曼螺杆菌感染治愈，肿瘤实现了完全的组织学和内镜缓解。5例患者中有3例在治疗前显示单克隆B细胞，其中2例PCR仍为阳性。在中位随访期24个月内，淋巴瘤未复发，也未再次感染海尔曼螺杆菌。
这些数据表明，海尔曼螺杆菌感染患者可能发生胃MALT淋巴瘤。这种感染的治愈可能导致MALT淋巴瘤完全缓解。
