伴有12号染色体短臂1区3带缺失的B细胞慢性淋巴细胞白血病中的c-myc和K-ras-2癌基因
c-myc and K-ras-2 oncogenes in B-cell chronic lymphocytic leukemia with del(12)(p13).
作者信息
Wang T Y, Samples D M, Dabdoub R, Prakash O
机构信息
Department of Molecular Oncology, Alton Ochsner Medical Foundation, New Orleans, LA 70121.
出版信息
Cancer Genet Cytogenet. 1991 Jan;51(1):125-30. doi: 10.1016/0165-4608(91)90018-p.
PMID:1984840
Abstract
Molecular and cytogenetic analyses were performed on chronic B-lymphocytic cell leukemia (CLL) from a 57-year-old male patient with del(12)(p13) anomaly. The deletion did not remove the K-ras-2 gene. However, c-myc gene amplification correlated with high-level expression, suggesting the involvement of this gene in the induction of neoplasia in this patient.
摘要
对一名患有del(12)(p13)异常的57岁男性慢性B淋巴细胞白血病（CLL）患者进行了分子和细胞遗传学分析。该缺失并未移除K-ras-2基因。然而，c-myc基因扩增与高水平表达相关，提示该基因参与了该患者肿瘤的诱发。
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