Lundgren R, Berger R, Kristoffersson U
Department of Urology, University Hospital, Lund, Sweden.
Cancer Genet Cytogenet. 1991 Jan;51(1):57-62. doi: 10.1016/0165-4608(91)90008-i.
The size of the heterochromatin C-bands on chromosomes has been reported to be associated with some, but by no means all, human malignancies. No studies along these lines have been performed in prostatic cancer. We therefore investigated the size, incidence of inversions, and symmetry versus asymmetry of C-band heteromorphisms on chromosomes 1, 9, and 16 in peripheral blood lymphocytes from 52 prostatic cancer patients and 183 healthy individuals. There were no differences in C-band heteromorphism on chromosomes 1, 9, and 16 between the patients and the controls. Neither were there any differences when patients with early-stage disease were compared with patients with more advanced cancer. Younger (aged less than 70 years) cancer patients had significantly higher frequencies of larger C-bands on chromosomes 1 (p less than 0.01) and 16 (p less than 0.001) than did patients aged more than 70 years at diagnosis. This could indicate a possible relationship between the amount of constitutive heterochromatin on chromosomes 1 and 16 and susceptibility to early development of prostatic cancer but could also result from the age differences between the two patient groups.
据报道，染色体上异染色质C带的大小与部分（但绝非全部）人类恶性肿瘤有关。目前尚未有针对前列腺癌进行的此类研究。因此，我们调查了52例前列腺癌患者和183名健康个体外周血淋巴细胞中1号、9号和16号染色体上C带异染色质的大小、倒位发生率以及对称与不对称情况。患者与对照组在1号、9号和16号染色体上的C带异染色质并无差异。早期疾病患者与癌症进展更严重的患者相比也无差异。诊断时年龄小于70岁的年轻癌症患者，其1号染色体（p<0.01）和16号染色体（p<0.001）上较大C带的频率显著高于70岁以上的患者。这可能表明1号和16号染色体上组成型异染色质的量与前列腺癌早期发生易感性之间存在潜在关系，但也可能是由于两组患者的年龄差异所致。
