[子宫内膜癌患者外周血淋巴细胞中1、9和16号染色体C带区段的多态性]
[Polymorphism of the C-band segments of chromosomes 1, 9 and 16 in the peripheral blood lymphocytes of patients with endometrial cancer].
作者信息
Polishchuk L Z, Nesina I P
出版信息
Tsitol Genet. 1993 Jul-Aug;27(4):66-71.
The paper presents results of investigation of constitutive heterochromatin of chromosomes 1, 9 and 16 in 23 patients with endometrial cancer and 5 women of the control group. The analysis was carried out on slides obtained by the routine method of the peripheral blood cell culture. The C-band segment variability was studied by the C-binding method. The investigation established an increase of polymorphism of constitutive heterochromatin in cancer patients, extreme variants and heteromorphism of homologues of chromosomes 1, 9 and 16. It is shown that polymorphism of the C-band on chromosomes 1, 9 and 16 in patients with cancer in their families increases as compared to the patients without cancer pathology in pedigrees.
本文介绍了对23例子宫内膜癌患者和5名对照组女性的1号、9号和16号染色体组成型异染色质的研究结果。分析是在通过外周血细胞培养常规方法获得的载玻片上进行的。采用C带结合法研究C带段变异性。研究发现癌症患者组成型异染色质的多态性增加，1号、9号和16号染色体同源染色体存在极端变异和异形性。结果表明，与家系中无癌症病理的患者相比，家族中有癌症患者的1号、9号和16号染色体C带多态性增加。
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