Strumpf I J, Drucker R D, Anders K H, Cohen S, Fajolu O
Kaiser Permanente Medical Center, Woodland Hills, Calif.
Chest. 1991 Jan;99(1):8-13. doi: 10.1378/chest.99.1.8.
A series of four patients with pulmonary infiltrates, pleural effusions, hypoxemia, peripheral eosinophilia, and symptoms of dyspnea, fatigue, and weakness is reported. Lung tissue obtained in three patients revealed interstitial pneumonitis, small-to-medium-vessel mixed-cell vasculitis, and alveolar exudate of histiocytes and eosinophils. All patients reported ingestion of L-tryptophan-containing products at a time when an association between L-tryptophan and the eosinophilia-myalgia syndrome was established. This clinical pattern of pulmonary involvement may be part of the continuum of the eosinophilia-myalgia syndrome. The pathophysiology of this syndrome and the relationship with the ingestion of L-tryptophan-containing products have not yet been identified.
报告了一组四名患者，他们有肺部浸润、胸腔积液、低氧血症、外周血嗜酸性粒细胞增多，以及呼吸困难、疲劳和虚弱等症状。三名患者的肺组织显示为间质性肺炎、中小血管混合细胞性血管炎，以及组织细胞和嗜酸性粒细胞的肺泡渗出物。所有患者均报告在L-色氨酸与嗜酸性粒细胞增多性肌痛综合征之间的关联确立之时，曾摄入含L-色氨酸的产品。这种肺部受累的临床模式可能是嗜酸性粒细胞增多性肌痛综合征连续过程的一部分。该综合征的病理生理学以及与摄入含L-色氨酸产品的关系尚未明确。
