Department of Psychiatry, Ulsan University Hospital, University of Ulsan College of Medicine, 290-3 Jeonha-dong, Dong-gu, Ulsan 682-714, Republic of Korea.
Neurosci Lett. 2010 Jan 1;468(1):7-11. doi: 10.1016/j.neulet.2009.10.046. Epub 2009 Oct 20.
Several studies have reported that brain-derived neurotrophic factor (BDNF) might be associated with nicotine dependence. However, there are few studies on BDNF levels in humans with nicotine dependence. In the present study, we compared the differences in plasma BDNF levels in patients with nicotine dependence and in healthy nonsmokers, and we investigated serial changes in plasma BDNF levels in patients with nicotine dependence following smoking cessation. Forty-five voluntary smokers and 66 nonsmokers were recruited in this study. Of the 45 smokers, 12 were taking varenicline, 21 were using a nicotine patch, and 12 were unaided in their cessation effort by their own choice. Plasma BDNF levels were measured at baseline using an enzyme-linked immunosorbent assay (both smokers and nonsmokers) and at weeks 4 and 12 after smoking cessation (abstinent smokers only). A total of 19 smokers were able to remain abstinent during the entire study period. Baseline plasma BDNF levels were significantly lower in smokers compared to nonsmokers (F=4.410, p=0.002). The plasma BDNF levels in the abstinent smokers significantly increased from baseline after 4 weeks of smoking cessation (z=-2.86, p=0.004) but had a tendency of decrease in the period between weeks 4 and 12. We could not find differences in the plasma BDNF levels among the three smoker subgroups at week 12 following cessation. Changes in plasma BDNF levels might be related to the process of abstinence and the pathophysiology of nicotine dependence.
几项研究报道，脑源性神经营养因子（BDNF）可能与尼古丁依赖有关。然而，关于尼古丁依赖患者的 BDNF 水平的研究较少。在本研究中，我们比较了尼古丁依赖患者和健康非吸烟者之间血浆 BDNF 水平的差异，并研究了戒烟后尼古丁依赖患者血浆 BDNF 水平的连续变化。本研究共招募了 45 名自愿吸烟者和 66 名非吸烟者。在 45 名吸烟者中，12 名服用伐尼克兰，21 名使用尼古丁贴片，12 名自行选择戒烟。使用酶联免疫吸附试验（吸烟者和非吸烟者均）测量基线时和戒烟后 4 周和 12 周时的血浆 BDNF 水平（仅戒烟的吸烟者）。共有 19 名吸烟者在整个研究期间能够保持戒烟状态。与非吸烟者相比，吸烟者的基线血浆 BDNF 水平显著降低（F=4.410，p=0.002）。戒烟后 4 周，戒烟者的血浆 BDNF 水平从基线显著升高（z=-2.86，p=0.004），但在第 4 周到第 12 周之间有下降趋势。我们在戒烟后第 12 周时，在三个吸烟亚组之间未发现血浆 BDNF 水平的差异。血浆 BDNF 水平的变化可能与戒断过程和尼古丁依赖的病理生理学有关。
