National Breast Cancer Audit, Royal Australasian College of Surgeons, Australia.
Breast. 2009 Dec;18(6):378-81. doi: 10.1016/j.breast.2009.09.015. Epub 2009 Oct 22.
Breast cancer in males is much rare than in females so in practice, male breast cancer treatment is likely to follow the guidelines developed for female breast cancer patients. The objective of this study is to compare the characteristics and treatment pattern of male breast cancer patients with comparable subgroups of female breast cancer patients using data submitted to the National Breast Cancer Audit. This is a retrospective analysis of 151 male breast cancers diagnosed and treated between 2000 and 2008. Most of the male early breast cancer cases in this group were symptomatic ones in men aged >50 years with one invasive tumour. There was a similar proportion of lymph node positive cancer among males and females, although male breast cancer was more likely to be unifocal (P=0.007) and oestrogen receptor positive (P=0.001). Male breast cancer patients almost always underwent mastectomy and a significant proportion of them (11%) received no surgical treatment. There were no differences in axillary surgery although males were more likely to undergo a level 2 axillary surgery and less likely to have sentinel node biopsy. Male patients were significantly less likely to undergo radiotherapy, chemotherapy or hormonal therapy for oestrogen receptor positive tumours.
While the female oriented treatment guidelines are available, male patients with early breast cancer received different surgical and adjuvant treatment from comparable females.
男性乳腺癌比女性乳腺癌罕见得多，因此在实践中，男性乳腺癌的治疗可能遵循为女性乳腺癌患者制定的指南。本研究的目的是使用国家乳腺癌审计提交的数据，将男性乳腺癌患者的特征和治疗模式与可比的女性乳腺癌患者亚组进行比较。这是对 2000 年至 2008 年间诊断和治疗的 151 例男性乳腺癌的回顾性分析。该组中大多数男性早期乳腺癌病例为 50 岁以上男性的症状性肿瘤，且为单一浸润性肿瘤。男性和女性的淋巴结阳性癌症比例相似，尽管男性乳腺癌更可能为单一病灶（P=0.007）且雌激素受体阳性（P=0.001）。男性乳腺癌患者几乎总是接受乳房切除术，其中相当一部分（11%）未接受手术治疗。腋窝手术没有差异，尽管男性更有可能接受 2 级腋窝手术，而不太可能进行前哨淋巴结活检。男性患者雌激素受体阳性肿瘤接受放疗、化疗或激素治疗的可能性明显较低。
虽然有针对女性的治疗指南，但早期男性乳腺癌患者接受的手术和辅助治疗与可比的女性患者不同。
