Ophthalmic Research Group, School of Life and Health Sciences, Aston University, Birmingham, UK.
Br J Ophthalmol. 2010 Mar;94(3):328-31. doi: 10.1136/bjo.2009.167213. Epub 2009 Oct 22.
BACKGROUND/AIMS: The MacuScope uses a psychophysical technique called heterochromic flicker photometry to measure macular pigment optical density (MPOD). Our aim was to determine the measurement variability (noise) of the MacuScope.
Thirty-eight normally sighted participants who ranged in age from 19 to 46 years (25.7+/-7.6 years) were recruited from staff and students of Aston University. Data were collected by two operators, HB and JA, in two sessions separated by 1 week in order to assess test repeatability and reproducibility.
The overall mean MPOD for the cohort was 0.47+/-0.14. There was a significant negative correlation between MacuScope MPOD readings and age (r=-0.368, p=0.023). Coefficients were 0.45 and 0.58 for repeatability, and 0.49 and 0.36 for reproducibility. For each pair of results, there was a significant positive correlation between mean and difference MPOD values.
If MPOD is being monitored over time then any change less than 0.58 units should not be considered clinically significant as it is very likely to be due to instrument noise. The size of the coefficient appears to be positively correlated with MPOD.
背景/目的：MacuScope 使用一种称为异嗜性闪烁光度法的心理物理学技术来测量黄斑色素光密度（MPOD）。我们的目的是确定 MacuScope 的测量可变性（噪声）。
从阿斯顿大学的工作人员和学生中招募了 38 名视力正常的参与者，年龄在 19 至 46 岁之间（25.7+/-7.6 岁）。数据由两名操作员 HB 和 JA 在相隔一周的两次会议中收集，以评估测试的可重复性和再现性。
该队列的总体平均 MPOD 为 0.47+/-0.14。MacuScope MPOD 读数与年龄呈显著负相关（r=-0.368，p=0.023）。重复性的系数为 0.45 和 0.58，再现性的系数为 0.49 和 0.36。对于每一对结果，平均和差异 MPOD 值之间存在显著的正相关。
如果在一段时间内监测 MPOD，则任何小于 0.58 个单位的变化都不应被认为具有临床意义，因为它很可能是由于仪器噪声引起的。系数的大小似乎与 MPOD 呈正相关。
