Fetal and Neonatal Research Group, Department of Physiology, Monash University, Clayton, Vic., Australia.
Dev Neurosci. 2009;31(6):523-35. doi: 10.1159/000251907. Epub 2009 Oct 23.
Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys cahirinus) underwent caesarean-section delivery or 7.5 min of asphyxia at 37 days gestational age (term is 39 days). Brain histology was examined at 1 and 7 days of age, and behaviour was evaluated to 28 days of age. Asphyxiated offspring showed significant impairment in non-spatial memory and learning tasks, accompanied by central nervous system inflammation and increased apoptotic cell death but without the presence of large necrotic or cystic lesions.
出生窒息可导致感觉障碍、学习和记忆缺陷，而无脑损伤和严重运动缺陷。我们使用具有早熟胎儿发育的长胎龄物种，开发了一种轻度神经损伤和认知障碍的出生窒息模型。刺毛鼠（Acomys cahirinus）接受剖宫产或 37 天胎龄（足月为 39 天）时 7.5 分钟窒息。在 1 天和 7 天龄时检查脑组织病理学，并在 28 天龄时进行行为评估。窒息的后代在非空间记忆和学习任务中表现出明显的障碍，伴有中枢神经系统炎症和凋亡细胞死亡增加，但没有大的坏死或囊性病变。
