再生模型系统：棘鼠。
Model systems for regeneration: the spiny mouse, .
机构信息
Department of Biology & UF Genetics Institute, University of Florida, PO Box 118525, Gainesville, FL 32611, USA
Department of Biology & UF Genetics Institute, University of Florida, PO Box 118525, Gainesville, FL 32611, USA.
出版信息
Development. 2020 Feb 25;147(4):dev167718. doi: 10.1242/dev.167718.
Abstract
The spiny mouse, spp., is a recently described model organism for regeneration studies. For a mammal, it displays surprising powers of regeneration because it does not fibrose (i.e. scar) in response to tissue injury as most other mammals, including humans, do. In this Primer article, we review these regenerative abilities, highlighting the phylogenetic position of the spiny mouse relative to other rodents. We also briefly describe the tissues that have been used for regeneration studies and the common features of their regeneration compared with the typical mammalian response. Finally, we discuss the contribution that has made in understanding the general principles of regeneration and elaborate hypotheses as to why this mammal is successful at regenerating.
摘要
刺鼠是最近被描述的再生研究模式生物。作为一种哺乳动物，它具有惊人的再生能力，因为它不像大多数其他哺乳动物（包括人类）那样在组织损伤时发生纤维化（即瘢痕形成）。在这篇概述文章中，我们回顾了这些再生能力，突出了刺鼠相对于其他啮齿动物的进化地位。我们还简要描述了用于再生研究的组织以及它们的再生与典型哺乳动物反应的共同特征。最后，我们讨论了刺鼠在理解再生一般原理方面的贡献，并详细阐述了为什么这种哺乳动物能够成功再生的假设。
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本文引用的文献
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Front Immunol. 2020 Aug 7;11:1695. doi: 10.3389/fimmu.2020.01695. eCollection 2020.
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Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus.棘鼠（Acomys cahirinus）脊髓损伤后的分子和组织学结果。
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Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence.高度再生的哺乳动物的结缔组织成纤维细胞对 ROS 诱导的细胞衰老具有抗性。
Nat Commun. 2019 Sep 27;10(1):4400. doi: 10.1038/s41467-019-12398-w.
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