Department of Biology & UF Genetics Institute, University of Florida, PO Box 118525, Gainesville, FL 32611, USA
Department of Biology & UF Genetics Institute, University of Florida, PO Box 118525, Gainesville, FL 32611, USA.
Development. 2020 Feb 25;147(4):dev167718. doi: 10.1242/dev.167718.
The spiny mouse, spp., is a recently described model organism for regeneration studies. For a mammal, it displays surprising powers of regeneration because it does not fibrose (i.e. scar) in response to tissue injury as most other mammals, including humans, do. In this Primer article, we review these regenerative abilities, highlighting the phylogenetic position of the spiny mouse relative to other rodents. We also briefly describe the tissues that have been used for regeneration studies and the common features of their regeneration compared with the typical mammalian response. Finally, we discuss the contribution that has made in understanding the general principles of regeneration and elaborate hypotheses as to why this mammal is successful at regenerating.
刺鼠是最近被描述的再生研究模式生物。作为一种哺乳动物，它具有惊人的再生能力，因为它不像大多数其他哺乳动物（包括人类）那样在组织损伤时发生纤维化（即瘢痕形成）。在这篇概述文章中，我们回顾了这些再生能力，突出了刺鼠相对于其他啮齿动物的进化地位。我们还简要描述了用于再生研究的组织以及它们的再生与典型哺乳动物反应的共同特征。最后，我们讨论了刺鼠在理解再生一般原理方面的贡献，并详细阐述了为什么这种哺乳动物能够成功再生的假设。
