School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Obesity (Silver Spring). 2010 Jun;18(6):1183-7. doi: 10.1038/oby.2009.336. Epub 2009 Oct 22.
It is suggested that a large breast size among women may predict type 2 diabetes risk independent of BMI and waist circumference (WC). The purpose of this study was to determine the independent associations of breast volume with cardiometabolic risk factors and regional fat distribution. A total of 92 overweight or obese premenopausal women (age = 39.9 +/- 6.8 years) underwent full-body magnetic resonance imaging (MRI) for the assessment of breast volume, visceral adipose tissue (VAT), abdominal and lower-body subcutaneous AT (SAT), and intermuscular AT (IMAT), a 2-h oral glucose tolerance test (OGTT), and fasting phlebotomy for assessment of triglyceride, total, high-density lipoprotein-, and low-density lipoprotein-cholesterol levels. Breast volume was not associated with any of the cardiometabolic risk factors assessed (P > 0.05). However, VAT was consistently associated with a number of cardiometabolic risk factors (OGTT glucose, OGTT insulin, and triglyceride levels) after controlling for age, BMI, WC, breast volume, and the other AT depots. In univariate models, breast volume was positively associated with VAT, IMAT, and abdominal and lower-body SAT (P < 0.05). After controlling for age, BMI, and WC level, breast volume remained positively associated with VAT and IMAT (P < 0.05), such that women with the highest breast volume had approximately 1.1 and 1.3 kg more VAT and IMAT, respectively, but no more abdominal or lower-body SAT, by comparison to women with the smallest breast volume. Thus, the previously documented association between breast size and type 2 diabetes risk may be in part explained by excess VAT and/or IMAT deposition.
研究表明，女性乳房大小可能与 BMI 和腰围（WC）无关，可预测 2 型糖尿病的发病风险。本研究旨在确定乳房体积与心血管代谢危险因素和局部脂肪分布的独立相关性。共纳入 92 例超重或肥胖绝经前女性（年龄=39.9+/-6.8 岁），采用全身磁共振成像（MRI）评估乳房体积、内脏脂肪组织（VAT）、腹部和下半身皮下脂肪组织（SAT）以及肌间脂肪组织（IMAT），进行 2 小时口服葡萄糖耐量试验（OGTT）和空腹采血以评估甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平。乳房体积与评估的任何心血管代谢危险因素均无关（P＞0.05）。然而，VAT 与许多心血管代谢危险因素（OGTT 血糖、OGTT 胰岛素和甘油三酯水平）相关，且在控制年龄、BMI、WC、乳房体积和其他脂肪组织沉积后仍具有相关性。在单变量模型中，乳房体积与 VAT、IMAT 和腹部及下半身 SAT 呈正相关（P＜0.05）。在控制年龄、BMI 和 WC 水平后，乳房体积与 VAT 和 IMAT 仍呈正相关（P＜0.05），与乳房体积最小的女性相比，乳房体积最大的女性 VAT 和 IMAT 分别增加约 1.1 和 1.3kg，但腹部和下半身 SAT 没有增加。因此，先前研究中乳房大小与 2 型糖尿病发病风险之间的关联可能部分归因于 VAT 和/或 IMAT 沉积增加。
