Department of Diagnostic Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Eur Radiol. 2009 Oct;19 Suppl 5:S975-89. doi: 10.1007/s00330-009-1624-y.
Discussion at the 2nd Forum for Liver MRI: The International Primovist User Meeting on the use of the hepatocyte-specific contrast agent gadolinium-ethoxybenzyl-diethylene triamine penta-acetic acid (Gd-EOB-DTPA) is reported. Changes to the currently recommended Gd-EOB-DTPA imaging protocol were identified that can reduce the overall examination time. The potential benefits of 3-T MR imaging using Gd-EOB-DTPA have yet to be fully explored. Data show that Gd-EOB-DTPA-enhanced MRI allows identification of liver lesions and provides a differential diagnosis of hepatocellular nodules in the noncirrhotic and cirrhotic liver, based on vascularity, during the dynamic arterial, portal-venous and late phases, and during the hepatocytespecific phase. Current European, American and Japanese guidelines for the diagnosis of hepatocellular carcinoma need to take into account the recent rapid advances in liver imaging. Based on published clinical trials and the experience of the attendees in the use of Gd-EOB-DTPA in liver imaging, a new simplified, non-invasive diagnostic algorithm was proposed that would be applicable to both Eastern and Western clinical practice in the evaluation of hepatocarcinogenesis and hepatocellular carcinoma. Preliminary clinical experience suggests that Gd-EOB-DTPA may also provide an innovative and cost-effective one-stop approach for staging rectal cancer using wholebody imaging.
第二届肝脏 MRI 论坛讨论：使用肝细胞特异性对比剂钆塞酸二钠（Gd-EOB-DTPA）的国际普美显用户会议报告。确定了对当前推荐的 Gd-EOB-DTPA 成像方案的更改，这可以减少整个检查时间。使用 Gd-EOB-DTPA 的 3-T MR 成像的潜在优势尚未得到充分探索。数据显示，Gd-EOB-DTPA 增强 MRI 可以根据血管分布，在动态动脉期、门静脉期和晚期以及肝细胞特异性期，识别肝脏病变，并对非肝硬化和肝硬化肝脏中的肝细胞结节进行鉴别诊断。目前欧洲、美国和日本的肝细胞癌诊断指南需要考虑到肝脏成像的最新快速发展。基于已发表的临床试验和与会者在肝脏成像中使用 Gd-EOB-DTPA 的经验，提出了一种新的简化、非侵入性诊断算法，该算法将适用于评估肝细胞癌发生和肝细胞癌的东西方临床实践。初步临床经验表明，Gd-EOB-DTPA 还可以为使用全身成像对直肠癌进行分期提供一种创新且具有成本效益的一站式方法。
