Molecular Medicine Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Metab Brain Dis. 2009 Dec;24(4):673-84. doi: 10.1007/s11011-009-9169-y. Epub 2009 Oct 23.
Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.
维持大脑中适当的铁稳态很重要，但大脑中铁摄取的相关机制尚未完全阐明。在此，我们利用艾伦脑图谱分析了编码铁转运蛋白的信使 RNA 在大脑中的表达位置，结果表明几种重要的铁转运蛋白在脉络丛中高表达。根据对脉络丛表面积的最新估计，以及对脑内锰摄取的 MRI 成像研究，我们提出脉络丛在脑铁转运中的作用可能比之前认为的要大得多。
