夹竹桃叶中的两个新三萜类异构体。

Two new triterpenoid isomers from Nerium oleander leaves.

机构信息

HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

出版信息

Nat Prod Res. 2009;23(17):1603-8. doi: 10.1080/14786410802573958.

DOI:10.1080/14786410802573958

PMID:19851926

Abstract

Two new triterpenoid isomers alpha-neriursate (1) and beta-neriursate (2) have been isolated from the fresh, uncrushed leaves of Nerium oleander and their structures elucidated as 3alpha-acetophenoxy-urs-12-en-28-oic acid and 3beta-acetophenoxy-urs-12-en-28-oic acid, respectively. The structure elucidation is based on spectroscopic methods, including 1D ((1)H NMR, (13)C NMR) and 2D ((1)H-(1)H COSY, NOESY, HMQC, HMBC and J-resolved) NMR data and chemical transformation.

摘要

从夹竹桃新鲜未破碎的叶子中分离得到两种新的三萜异构体 α-neriursate（1）和β-neriursate（2），并将其结构鉴定为 3α-乙酰苯氧基-urs-12-烯-28-酸和 3β-乙酰苯氧基-urs-12-烯-28-酸。结构鉴定基于光谱方法，包括 1D（（1）H NMR、（13）C NMR）和 2D（（1）H-（1）H COSY、NOESY、HMQC、HMBC 和 J-分辨）NMR 数据和化学转化。