Department of Epidemiology and Biostatistics, Department of Psychiatry, Vrije Universiteit Amsterdam, the Netherlands.
Int J Geriatr Psychiatry. 2010 Jul;25(7):679-87. doi: 10.1002/gps.2407.
The prevalence rate of depression among patients with Parkinson's disease (PD) has been estimated at 25%, although prevalence figures range between 7-76%. Relatively few studies on PD and depression are based on random samples in the general population. Some depressive symptoms can also be understood as symptoms of parkinsonism, and the current study aims to describe which 'overlap' symptoms can be identified in a community sample.
Data are employed from the EURODEP collaboration. Nine study centres, from eight western European countries, provided data on depression (most GMS-AGECAT), depressive symptoms (EURO-D items and anxiety), parkinsonism (self-report of PD or clinical signs of PD), functional disability and dementia diagnosis.
Data were complete for 16 313 respondents, aged 65 and older; 306 (1.9%) reported or had signs of parkinsonism. The rate of depression was about twice as high among respondents with parkinsonism (unadjusted Odds Ratio 2.44, 95% Confidence Interval 1.88-3.17), also among those without functional disability. 'Overlap' symptoms between parkinsonism and depression, were represented by motivation and concentration problems, appetite problems and especially the symptom of fatigue (energy loss). However, principal component analysis showed that these 'overlap' symptoms loaded on different factors of the EURO-D scale.
As among clinical patients with PD, depression is highly common in community dwelling older people with parkinsonism, even among those without functional disability. Although fatigue did not strongly relate to motivational symptoms, both types of 'overlap' symptoms possibly trigger a final common pathway towards a full depressive syndrome.
帕金森病（PD）患者的抑郁症患病率估计为 25%，尽管患病率在 7-76%之间。基于普通人群的随机样本进行的 PD 和抑郁症的研究相对较少。一些抑郁症状也可以被理解为帕金森病的症状，本研究旨在描述在社区样本中可以识别哪些“重叠”症状。
本研究使用了 EURODEP 合作的数据。来自八个西欧国家的九个研究中心提供了关于抑郁症（大多数使用 GMS-AGECAT 进行评估）、抑郁症状（EURO-D 项目和焦虑）、帕金森病（自我报告或临床 PD 迹象）、功能障碍和痴呆诊断的数据。
共有 16313 名年龄在 65 岁及以上的受访者完成了数据，其中 306 人（1.9%）报告或有帕金森病迹象。有帕金森病的受访者的抑郁症发生率约为两倍（未经调整的优势比 2.44，95%置信区间 1.88-3.17），且无功能障碍的受访者中也存在同样情况。帕金森病和抑郁症之间的“重叠”症状表现为动机和注意力问题、食欲问题，特别是疲劳（能量损失）症状。然而，主成分分析显示，这些“重叠”症状在 EURO-D 量表的不同因子上加载。
与临床 PD 患者一样，社区居住的帕金森病老年人中抑郁症非常常见，即使在没有功能障碍的人群中也是如此。虽然疲劳与动机症状没有很强的关联，但这两种类型的“重叠”症状可能会引发一个通向完整抑郁综合征的共同途径。
