Ehrt Uwe, Brønnick Kolbjørn, Leentjens Albert F G, Larsen Jan Petter, Aarsland Dag
Section of Geriatric Psychiatry, Stavanger University Hospital, Norway.
Int J Geriatr Psychiatry. 2006 Mar;21(3):252-8. doi: 10.1002/gps.1456.
Depression is a common neuropsychiatric syndrome in Parkinson's disease (PD), and may be etiologically related to the neurochemical changes accompanying this disease. It is still unclear whether the disturbances of neurotransmitter activities lead to a specific profile of depressive symptoms, that is characteristic for PD and differs from that in depressed patients without PD.
We compared the individual depressive symptoms of 145 non-demented depressed patients with PD and 100 depressed patients without PD by comparing item scores on the Montgomery-Asberg Depression Rating Scale by way of MANCOVA.
The severity of depression and the level of cognitive functioning in depressed PD patients were comparable with that of depressed control subjects. However, patients with PD showed significant less reported sadness, less anhedonia, less feelings of guilt and, slightly less loss of energy, but more concentration problems than depressed control subjects.
The profile of depressive symptoms in PD differs from that in depressed subjects without PD. This finding is important for the conceptualisation and clinical diagnosis of depression in PD.
抑郁症是帕金森病（PD）中常见的神经精神综合征，可能在病因上与该疾病伴随的神经化学变化有关。目前尚不清楚神经递质活动紊乱是否会导致特定的抑郁症状谱，即PD所特有的且不同于无PD的抑郁症患者的症状谱。
我们通过多变量协方差分析比较蒙哥马利-艾斯伯格抑郁评定量表的项目得分，对145例非痴呆的PD抑郁症患者和100例无PD的抑郁症患者的个体抑郁症状进行了比较。
PD抑郁症患者的抑郁严重程度和认知功能水平与抑郁症对照受试者相当。然而，与抑郁症对照受试者相比，PD患者报告的悲伤情绪明显较少、快感缺乏较少、内疚感较少，精力丧失也略少，但注意力问题较多。
PD患者的抑郁症状谱与无PD的抑郁症患者不同。这一发现对于PD中抑郁症的概念化和临床诊断具有重要意义。
