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Mechanistic studies on the reaction between R2N-NONOates and aquacobalamin: evidence for direct transfer of a nitroxyl group from R2N-NONOates to cobalt(III) centers.

作者信息

Hassanin Hanaa A, Hannibal Luciana, Jacobsen Donald W, El-Shahat Mohamed F, Hamza Mohamed S A, Brasch Nicola E

机构信息

Department of Chemistry and School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.

出版信息

Angew Chem Int Ed Engl. 2009;48(47):8909-13. doi: 10.1002/anie.200904360.

DOI:10.1002/anie.200904360
PMID:19852010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2830066/
Abstract
摘要

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Chem Mater. 2008 Jan 1;20(1):239-249. doi: 10.1021/cm702526q.
2
Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs.基于连二亚硝酸酯的一氧化氮前药的细胞可渗透酯类。
Org Lett. 2008 Nov 20;10(22):5155-8. doi: 10.1021/ol8020989. Epub 2008 Oct 29.
3
Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity.O2-糖基化二氮烯二醇盐家族潜在前药的水解反应活性趋势。将一氧化氮靶向巨噬细胞以发挥抗利什曼原虫活性。
J Med Chem. 2008 Jul 10;51(13):3961-70. doi: 10.1021/jm8000482. Epub 2008 Jun 6.
4
Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation.释放一氧化氮的金属二氮烯二醇盐配合物强烈诱导血管舒张和内皮细胞增殖。
ChemMedChem. 2008 Jul;3(7):1039-47. doi: 10.1002/cmdc.200700354.
5
Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.一氧化氮介导的钙/钙调蛋白依赖性蛋白激酶II的调节
Biochem J. 2008 Jun 1;412(2):223-31. doi: 10.1042/BJ20071195.
6
Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound.抗癌先导化合物JS-K的结构类似物的合成及其体外抗白血病活性
Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3. doi: 10.1016/j.bmcl.2007.12.044. Epub 2008 Jan 4.
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Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.谷胱甘肽激活的一氧化氮前药的合成、一氧化氮释放及抗白血病活性：抗癌先导化合物PABA/NO的结构类似物
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