Ouyang Jun, Yin Hong-Lin, Lu Zhen-Feng, Zhou Hang-Bo, Zhou Xiao-Jun
Department of Pathology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2009 Aug;15(8):733-7.
To investigate the clinicopathological features of primary Burkitt lymphoma of the seminal vesicle.
We reported the clinical characteristics, histological changes and the results of immunohistochemical staining and molecular in situ hybridization of 1 case of primary Burkitt lymphoma of the seminal vesicle. We also reviewed the related literature and studied the pathomorphological characteristics and differential diagnosis of the tumor.
The characteristic manifestations of the patient were frequent micturition with dysuria, followed by inguinal lymphadenectasis 2 months later. Medical imaging showed a diffuse and monotonous infiltration of neoplastic cells with scanty cytoplasm and a few mitosis images. Microscopy displayed a starry sky pattern. The tumor cells were positive for CD10, CD20, CD79alpha, Bcl-6 and EBER in situ hybridization, but negative for CD3, CD6 and Cyclin D1. The Ki-67 index was > 95%.
Primary Burkitt lymphoma of the seminal vesicle is a very rare tumor with aggressive behavior. The pathological diagnosis of the tumor depends on histopathological examination and immunohistochemical techniques. However it should be differentiated from diffuse large B-cell lymphoma, lymphoblastic lymphoma and small cell carcinoma of the seminal vesicle or prostate gland.
探讨精囊原发性伯基特淋巴瘤的临床病理特征。
我们报告了1例精囊原发性伯基特淋巴瘤的临床特征、组织学变化以及免疫组化染色和分子原位杂交结果。我们还复习了相关文献，研究了该肿瘤的病理形态学特征及鉴别诊断。
患者的特征性表现为尿频伴排尿困难，2个月后出现腹股沟淋巴结肿大。医学影像显示肿瘤细胞弥漫性、单一性浸润，胞质稀少，有少量有丝分裂图像。显微镜下呈现满天星图案。肿瘤细胞CD10、CD20、CD79α、Bcl-6阳性，原位杂交EBER阳性，但CD3、CD6和Cyclin D1阴性。Ki-67指数>95%。
精囊原发性伯基特淋巴瘤是一种非常罕见的具有侵袭性的肿瘤。该肿瘤的病理诊断依赖于组织病理学检查和免疫组化技术。然而，它应与弥漫性大B细胞淋巴瘤、淋巴母细胞淋巴瘤以及精囊或前列腺小细胞癌相鉴别。
