一家教学医院的念珠菌血症及抗真菌药敏试验

Candidaemia and antifungal susceptibility testing in a teaching hospital.

作者信息

Tzar M N, Shamim A S

机构信息

Department of Medical Microbiology & Immunology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.

出版信息

Med J Malaysia. 2009 Mar;64(1):61-4.

PMID:19852325

Abstract

We reviewed cases of candidaemia at Universiti Kebangsaan Malaysia Medical Centre from 1st January 2005 to 30th June 2006. All blood cultures positive for Candida species or its teleomorphs within the study period were identified and antifungal susceptibility testing was performed. Out of 50 blood isolates, 20 (40%) were identified as Candida albicans, 16 (32%) C. tropicalis, five (10%) C. parapsilosis, three (6%) C. famata, two (4%) C. glabrata, two (4%) Pichia ohmeri, one (2%) C. krusei and one (2%) P. etchell/carsonii. Susceptibility to amphotericin B was 100%, fluconazole 90%, itraconazole 40%, ketoconazole 88%, 5-flucytosine 98% and voriconazole 98%.

摘要

我们回顾了马来西亚国民大学医学中心2005年1月1日至2006年6月30日期间念珠菌血症的病例。对研究期间所有念珠菌属或其有性型血培养阳性的样本进行了鉴定，并进行了抗真菌药敏试验。在50株血液分离株中，20株（40%）被鉴定为白色念珠菌，16株（32%）为热带念珠菌，5株（10%）为近平滑念珠菌，3株（6%）为季也蒙念珠菌，2株（4%）为光滑念珠菌，2株（4%）为奥默毕赤酵母，1株（2%）为克柔念珠菌，1株（2%）为埃切里/卡森毕赤酵母。两性霉素B的药敏率为100%，氟康唑为90%，伊曲康唑为40%，酮康唑为88%，5-氟胞嘧啶为98%，伏立康唑为98%。