López de Guzmán A, de D García Díaz J, Díez-Pérez de la Vacas M I, Cuende Quintana E, Sánchez Atrio A, Sivera Monzó I
Servicio de Medicina Interna, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Rev Clin Esp. 2009 Oct;209(9):428-32. doi: 10.1016/s0014-2565(09)72515-9.
Rheumatoid arthritis (RA) is characterized by high cardiovascular (CV) mortality, which has been related to systemic inflammation. Our aim was to analyze coronary calcification by computed tomography and subclinical myocardial dysfunction evaluated by brain natriuretic peptide (BNP) levels and an electrocardiogram in RA patients and its relationship with disease characteristics. Seventy-three RA patients and same number of controls formed by osteoarthritis patients were studied, all without a background of cardiovascular clinical events. RA patients had a higher calcium score than the control group (19.2% vs. 11%; p=0.17)), this being associated with disease duration. BNP levels (90.0 vs. 45.4; p=0.003), corrected QT length, large QT frequency and silent myocardial infarct were higher in the RA group. In conclusion, RA patients showed more coronary calcification frequency than in general population and more biochemical and electrocardiogram myocardial subclinical dysfunction signs.
类风湿性关节炎（RA）的特点是心血管（CV）死亡率高，这与全身炎症有关。我们的目的是通过计算机断层扫描分析RA患者的冠状动脉钙化情况，并通过脑钠肽（BNP）水平和心电图评估亚临床心肌功能障碍，以及分析其与疾病特征的关系。我们研究了73例RA患者以及由骨关节炎患者组成的相同数量的对照组，所有患者均无心血管临床事件背景。RA患者的钙评分高于对照组（19.2%对11%；p=0.17），这与病程相关。RA组的BNP水平（90.0对45.4；p=0.003）、校正QT间期、QT离散度增加和无症状心肌梗死发生率更高。总之，RA患者的冠状动脉钙化频率高于一般人群，且有更多生化和心电图亚临床心肌功能障碍迹象。
