Krishnamoorthy Bhuvaneswari, Najam Osman, Khan Ursalan A, Waterworth Paul, Fildes James E, Yonan Nizar
Department of Cardiothoracic Surgery, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom.
Ann Thorac Surg. 2009 Nov;88(5):1445-9. doi: 10.1016/j.athoracsur.2009.06.047.
Dermabond (Ethicon UK, Edinburgh, United Kingdom) is a topical skin adhesive used for surgical wound closure, with purported advantages over conventional sutures on cosmetic outcomes, cost benefits, and operative times. This study compared results of skin closure using Dermabond and subcuticular sutures after coronary artery bypass grafting (CABG).
The study prospectively enrolled and randomized 106 patients who underwent CABG. The groups received closure with Dermabond skin glue or subcuticular sutures (n = 53 each) after saphenous vein harvesting using the bridging technique. Wound closure time for the two methods was recorded. Cosmetic appearance was assessed using the Hollander, the Vancouver, and the visual analog scale. Patient satisfaction was recorded before discharge and at week 6.
There were no significant differences in the total operative time between the two groups (p = 0.43). Closure time was significantly shorter in the Dermabond group (p = 0.017). Patients in the Dermabond group also reported superior cosmetic outcome at weeks 1 (p < 0.001) and 6 (p = 0.001) and improved patient satisfaction (p < 0.001).
Dermabond has demonstrated superiority over traditional subcuticular skin sutures in terms of closure time, cosmetic appearance, and patient satisfaction. This technique provides a novel method of wound closure after CABG.
皮肤粘合剂（英国爱丁堡强生公司）是一种用于手术伤口闭合的局部皮肤粘合剂，据称在美容效果、成本效益和手术时间方面优于传统缝线。本研究比较了冠状动脉搭桥术（CABG）后使用皮肤粘合剂和皮下缝线进行皮肤闭合的效果。
本研究前瞻性纳入并随机分配了106例行CABG的患者。两组在采用桥接技术采集大隐静脉后，分别使用皮肤粘合剂或皮下缝线进行闭合（每组n = 53）。记录两种方法的伤口闭合时间。使用霍兰德、温哥华和视觉模拟量表评估美容外观。在出院前和第6周记录患者满意度。
两组的总手术时间无显著差异（p = 0.43）。皮肤粘合剂组的闭合时间显著缩短（p = 0.017）。皮肤粘合剂组的患者在第1周（p < 0.001）和第6周（p = 0.001）也报告了更好的美容效果，患者满意度提高（p < 0.001）。
在闭合时间、美容外观和患者满意度方面，皮肤粘合剂已证明优于传统的皮下皮肤缝线。该技术为CABG术后伤口闭合提供了一种新方法。
