Peroni D G, Pescollderungg L, Piacentini G L, Pollini F, De Luca G, Boner A L
Department of Pediatrics, University of Verona, Verona, Italy.
Allergol Immunopathol (Madr). 2009 Nov-Dec;37(6):281-4. doi: 10.1016/j.aller.2009.05.007.
The role of infections on the development of atopy is still widely debated. We aimed to evaluate the effects of neonatal severe sepsis and consequent antibiotic treatment on the development of atopy and allergic diseases.
A retrospective enrollment at school age of children with a clear history of neonatal sepsis (NS) was performed from registers of neonatal intensive care units. A normal control was assigned to each patient with sepsis. Thirty six cases with sepsis (18 males, 18 females) and 36 controls (21 males, 15 females) were selected (8.5+/-3.6 yrs). Physical examination and lung function evaluation were performed. Atopic status was verified by blood eosinophil count, total IgE serum level and skin prick tests (SPT).
SPT positivity for at least one allergen was present in 30% of subjects in both groups. No difference for all investigated parameters between groups and no influence by other factors such as familiarity or gender was observed. No correlation was associated to NS history.
Neonatal sepsis, even if clinically severe and dramatic, could represent an event too limited and really precocious in life to influence the development of immune response. Furthermore, other factors, besides infections, may influence the atopic future of newborns.
感染在特应性疾病发生发展中的作用仍存在广泛争议。我们旨在评估新生儿重症败血症及随后的抗生素治疗对特应性疾病和过敏性疾病发生发展的影响。
从新生儿重症监护病房登记册中对有明确新生儿败血症（NS）病史的儿童进行学龄期回顾性招募。为每位败血症患者分配一名正常对照。选取36例败血症患儿（男18例，女18例）和36例对照（男21例，女15例）（年龄8.5±3.6岁）。进行体格检查和肺功能评估。通过血液嗜酸性粒细胞计数、总IgE血清水平和皮肤点刺试验（SPT）来验证特应性状态。
两组中30%的受试者对至少一种变应原SPT呈阳性。两组间所有研究参数均无差异，且未观察到受家族史或性别等其他因素的影响。与NS病史无相关性。
新生儿败血症，即使临床上严重且危急，可能是一个在生命中过于有限且真正过早发生的事件，不足以影响免疫反应的发展。此外，除感染外，其他因素可能会影响新生儿未来患特应性疾病的情况。
