特应性、IgE 和嗜酸性阳离子蛋白浓度、特异性 IgE 阳性、皮肤 T 细胞淋巴瘤中的嗜酸性粒细胞计数。

Atopy, IgE and eosinophilic cationic protein concentration, specific IgE positivity, eosinophil count in cutaneous T Cell lymphoma.

机构信息

Department of Dermatology, Vakif Gureba Training Hospital, Istanbul, Turkey.

出版信息

Int J Dermatol. 2010 Apr;49(4):390-5. doi: 10.1111/j.1365-4632.2010.04228.x.

DOI:10.1111/j.1365-4632.2010.04228.x

PMID:20465692

Abstract

BACKGROUND

Even though several case studies have reported a relationship between Cutaneous T Cell Lymphoma (CTCL) and atopic diathesis, this association is still controversial. The aim of this study was to investigate the actual presence of atopic status in CTCL patients.

METHODS

A total of 78 patients with both clinical and histological features typical of CTCL and 77 control cases from our outpatient dermatology clinic were included in this study. After initial evaluation and staging, all patients were investigated for history of atopic disease, serum total IgE and eosinophil cationic protein concentration (ECP), eosinophil count, serum specific IgE, and skin prick test positivity.

RESULTS

Personal atopy in CTCL group was 23,1% (n = 18) and familial atopy was 9.0% (n = 7) whereas in the control group, these values were 11.7% (n = 9) and 7.8% (n = 6), respectively. There was no statistically significant difference, however, the number of atopic patients were higher in CTCL group than the control group (p = 0.151). Serum total IgE levels were significantly increased in patients with CTCL when compared to control group (p = 0.04). Serum specific IgE panel and prick test positivity between patients and controls were significantly different, respectively (p = 0. 03) (p = 0. 00). Eosinophil counts and ECP levels were not significantly different, respectively (p = 0.10) (p = 0.885). In high stages of CTCL, patients were found to have elevated IgE, ECP levels and eosinophil count. These results were statistically significant (p = 0.011) (p = 0.009) (p = 0.007).

CONCLUSION

Eventhough the number of patients with atopy in the CTCL group was higher than the control cases, there was no significant different. On the other hand high levels of serum IgE, elevated eosinophil count and specific IgE positivity may be found in CTCL patients with or without atopic disease, especially with high stages.

摘要

背景

尽管有几项病例研究报告了皮肤 T 细胞淋巴瘤（CTCL）与特应性素质之间的关系，但这种关联仍存在争议。本研究的目的是调查 CTCL 患者中特应性状态的实际存在情况。

方法

本研究共纳入 78 例具有 CTCL 临床和组织学特征的患者和 77 例来自我们皮肤科门诊的对照病例。在初步评估和分期后，所有患者均接受了特应性疾病史、血清总 IgE 和嗜酸性粒细胞阳离子蛋白浓度（ECP）、嗜酸性粒细胞计数、血清特异性 IgE 和皮肤点刺试验阳性的检查。

结果

CTCL 组的个人特应性为 23.1%（n=18），家族特应性为 9.0%（n=7），而对照组分别为 11.7%（n=9）和 7.8%（n=6）。然而，两组之间的差异无统计学意义，但 CTCL 组的特应性患者数量高于对照组（p=0.151）。与对照组相比，CTCL 患者的血清总 IgE 水平显著升高（p=0.04）。患者和对照组之间的血清特异性 IgE 谱和皮肤点刺试验阳性率存在显著差异（p=0.03）（p=0.00）。嗜酸性粒细胞计数和 ECP 水平无显著差异（p=0.10）（p=0.885）。在 CTCL 的高分期中，发现患者的 IgE、ECP 水平和嗜酸性粒细胞计数升高。这些结果具有统计学意义（p=0.011）（p=0.009）（p=0.007）。