Ankara University School of Medicine Department of Obstetrics and Gynecology, Ankara, Turkey.
Best Pract Res Clin Obstet Gynaecol. 2010 Feb;24(1):113-26. doi: 10.1016/j.bpobgyn.2009.09.002. Epub 2009 Oct 23.
Although still experimental, cryopreservation and transplantation techniques for ovarian tissue have been well described, and a number of successful human pregnancies have occurred. Ovarian cryopreservation is the only fertility preservation procedure that can be offered to prepubertal children, and when cytotoxic treatment is urgent. There are two main approaches for autotransplantation of human ovarian tissue. In the heterotopic transplantation, cortical fragments can be grafted subcutaneously at various sites whereas in orthotopic transplantation cortical pieces are transplanted into its original location. Both approaches have their own advantages and disadvantages. While natural pregnancy can occur in orthotopic transplantation, heterotopic transplantation may be indicated if the pelvis is not suitable for transplantation due to previous radiation or severe scar formation. Furthermore, tissue monitoring may be easier in the heterotopic site. In this article, we reviewed the indications, limitations, risks and transplantation techniques for ovarian tissue.
虽然仍然处于试验阶段，但卵巢组织的冷冻保存和移植技术已经得到了很好的描述，并且已经有许多成功的人类妊娠案例。卵巢冷冻保存是唯一可以提供给青春期前儿童的生育力保存程序，并且在细胞毒性治疗紧急时使用。人类卵巢组织的自体移植有两种主要方法。在异位移植中，可以将皮质碎片移植到皮下的各个部位，而在原位移植中，皮质片则被移植到其原始位置。这两种方法各有优缺点。虽然在原位移植中可以自然妊娠，但如果骨盆由于先前的辐射或严重的疤痕形成而不适合移植，则可能需要进行异位移植。此外，在异位部位进行组织监测可能更容易。本文综述了卵巢组织的适应证、局限性、风险和移植技术。
