定义脱髓鞘疾病中的染色质景观。
Defining the chromatin landscape in demyelinating disorders.
机构信息
Department of Neuroscience and Genetics and Genomic Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1065, New York, NY 10029, USA.
出版信息
Neurobiol Dis. 2010 Jul;39(1):47-52. doi: 10.1016/j.nbd.2009.10.014. Epub 2009 Oct 22.
Abstract
An intricate network of epigenetic factors regulates cell differentiation by modulating the chromatin structure and ultimately affecting gene expression. This review describes the chromatin landscape defining oligodendrocyte progenitor differentiation during development and remyelination. We shall discuss the current knowledge regarding modifications of chromatin components during the progression of progenitors into myelinating cells and discuss the potential contribution of histone variants, microRNAs, and DNA methylation. We shall also briefly address how changes to this chromatin landscape can disturb this natural progression and alter the capacity to remyelinate.
摘要
一个错综复杂的表观遗传因子网络通过调节染色质结构来调节细胞分化，最终影响基因表达。本综述描述了在发育和髓鞘再生过程中定义少突胶质前体细胞分化的染色质景观。我们将讨论在祖细胞向髓鞘细胞分化过程中染色质成分修饰的最新知识，并讨论组蛋白变体、microRNAs 和 DNA 甲基化的潜在作用。我们还将简要讨论这种染色质景观的变化如何干扰这种自然进程并改变髓鞘再生的能力。
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