Copray Sjef, Huynh Jimmy Long, Sher Falak, Casaccia-Bonnefil Patrizia, Boddeke Erik
Department of Neuroscience, University Medical Centre Groningen, Groningen, The Netherlands.
Glia. 2009 Nov 15;57(15):1579-87. doi: 10.1002/glia.20881.
The process of oligodendrocyte differentiation is regulated by a dynamic interaction between a genetic and an epigenetic program. Recent studies, addressing nucleosomal histone modifications have considerably increased our knowledge regarding epigenetic regulation of gene expression during oligodendrocyte development and aging. These results have generated new hypotheses regarding the mechanisms underlying the decreased efficiency of endogenous remyelination in response to demyelinating injuries with increasing age. In this review, we present an overview of the epigenetic mechanisms regulating gene expression at specific stages of oligodendrocyte differentiation and maturation as well as the changes that occur with aging.
少突胶质细胞分化过程受遗传程序和表观遗传程序之间的动态相互作用调控。近期针对核小体组蛋白修饰的研究极大地增加了我们对少突胶质细胞发育和衰老过程中基因表达表观遗传调控的认识。这些结果产生了关于随着年龄增长,内源性髓鞘再生对脱髓鞘损伤反应效率降低的潜在机制的新假设。在本综述中,我们概述了在少突胶质细胞分化和成熟的特定阶段调节基因表达的表观遗传机制以及衰老过程中发生的变化。