Diplock A T
Division of Biochemistry, United Medical School, University of London, Guy's Hospital, UK.
Am J Clin Nutr. 1991 Jan;53(1 Suppl):189S-193S. doi: 10.1093/ajcn/53.1.189Sb.
Interest in free radical events has stimulated speculation that their disorder may be involved in a number of diseases. The reduction of dioxygen to water involves several active intermediates. The control of this depends on the integrity of an enzymatic system that requires adequate intake of selenium, copper, zinc, and manganese; if their level of intake is low, proliferation of active oxygen metabolites may occur. Targets for attack are DNA, proteins, and polyunsaturated phospholipids. Peroxidation of polyunsaturated phospholipids will result in disruption of membrane architecture. Vitamin E, perhaps with ascorbic acid, can prevent this, and vitamin A and beta-carotene also intervene. The implication of this in the etiology of a number of diseases depends on theory and on evidence linking low intake of the antioxidant nutrients with a high disease incidence. Improvements in epidemiology have resulted in glimpses into what may prove to be links between diet and disease.
对自由基事件的关注引发了一种推测，即它们的紊乱可能与多种疾病有关。将二氧还原为水涉及几种活性中间体。对此的控制取决于一个酶系统的完整性，该系统需要充足摄入硒、铜、锌和锰；如果它们的摄入量低，活性氧代谢产物可能会增殖。攻击目标是DNA、蛋白质和多不饱和磷脂。多不饱和磷脂的过氧化将导致膜结构的破坏。维生素E可能与抗坏血酸一起可以预防这种情况，维生素A和β-胡萝卜素也会起到干预作用。这在多种疾病病因学中的意义取决于理论以及将抗氧化营养素低摄入量与高疾病发生率联系起来的证据。流行病学的进步使人们得以瞥见饮食与疾病之间可能存在的联系。
