Morax S, Badelon I
Fondation A. de Rothschild, Service de Chirurgie Plastique Reconstructive Orbito-palpébrale-Neuro-ophtalmologie, 75940 Paris, France.
J Fr Ophtalmol. 2009 Oct;32(8):589-99. doi: 10.1016/j.jfo.2009.09.001. Epub 2009 Oct 23.
Dysthyroid orbitopathy is a disease that is edematous and inflammatory, generally chronic, sometimes subacute or acute, and is characterized by exophthalmos in the majority of cases, retraction of the lid, restrictive strabismus with diplopia, corneal ulceration, ocular hypertension, and compressive optic neuropathy. Proptosis is the cardinal sign. Exophthalmos is frequently axial and is bilateral in 85%-90% of cases. Displacement of the globe in the vertical and horizontal axes is not rare, particularly when intense enlargement of an extraocular muscle produces a mass effect. Proptosis stems from a conflict for the space in the orbital cavity. The infiltration of the fat, muscles, and lacrimal gland by lymphocytes, plasma cells, and mucopolysaccharides, which are very hydrophilic, all contribute to the orbitopathy. The majority of patients with minimal exophthalmos do not require special treatment since they tend to improve spontaneously. In severe forms, it is important to evaluate the activity for steroid use to eliminate the inflammation in the soft tissues and to make rehabilitative surgery possible under better conditions. When a good response is not obtained, radiotherapy is evaluated. The surgical treatment by bone orbital decompression and sometimes lipectomy is indicated in inactive forms, disfiguring exophthalmos, certain particular cases such as dysthyroid optic neuropathy, ocular hypertension, corneal exposition.
甲状腺功能异常性眼眶病是一种具有水肿性和炎症性的疾病,通常为慢性,有时为亚急性或急性,多数病例的特征为眼球突出、眼睑退缩、伴有复视的限制性斜视、角膜溃疡、眼压升高以及压迫性视神经病变。眼球突出是主要体征。眼球突出多为轴性,85% - 90%的病例为双侧性。眼球在垂直和水平轴向上移位并不少见,尤其是当一条眼外肌强烈肿大产生占位效应时。眼球突出源于眶腔内空间的争夺。淋巴细胞、浆细胞和非常亲水的粘多糖对脂肪、肌肉和泪腺的浸润都促成了眼眶病。大多数轻度眼球突出的患者无需特殊治疗,因为他们往往会自行好转。在严重的情况下,评估使用类固醇的活性很重要,以消除软组织炎症,并在更好的条件下进行修复性手术。当未获得良好反应时,需评估放疗。对于静止型、毁容性眼球突出、某些特殊情况如甲状腺功能异常性视神经病变、眼压升高、角膜暴露等,可采用眼眶骨减压手术,有时还需行脂肪切除术。