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[巴泽多病性突眼]

[Basedow exophthalmos].

作者信息

Morax S, Badelon I

机构信息

Fondation A. de Rothschild, Service de Chirurgie Plastique Reconstructive Orbito-palpébrale-Neuro-ophtalmologie, 75940 Paris, France.

出版信息

J Fr Ophtalmol. 2009 Oct;32(8):589-99. doi: 10.1016/j.jfo.2009.09.001. Epub 2009 Oct 23.

DOI:10.1016/j.jfo.2009.09.001
PMID:19853965
Abstract

Dysthyroid orbitopathy is a disease that is edematous and inflammatory, generally chronic, sometimes subacute or acute, and is characterized by exophthalmos in the majority of cases, retraction of the lid, restrictive strabismus with diplopia, corneal ulceration, ocular hypertension, and compressive optic neuropathy. Proptosis is the cardinal sign. Exophthalmos is frequently axial and is bilateral in 85%-90% of cases. Displacement of the globe in the vertical and horizontal axes is not rare, particularly when intense enlargement of an extraocular muscle produces a mass effect. Proptosis stems from a conflict for the space in the orbital cavity. The infiltration of the fat, muscles, and lacrimal gland by lymphocytes, plasma cells, and mucopolysaccharides, which are very hydrophilic, all contribute to the orbitopathy. The majority of patients with minimal exophthalmos do not require special treatment since they tend to improve spontaneously. In severe forms, it is important to evaluate the activity for steroid use to eliminate the inflammation in the soft tissues and to make rehabilitative surgery possible under better conditions. When a good response is not obtained, radiotherapy is evaluated. The surgical treatment by bone orbital decompression and sometimes lipectomy is indicated in inactive forms, disfiguring exophthalmos, certain particular cases such as dysthyroid optic neuropathy, ocular hypertension, corneal exposition.

摘要

甲状腺功能异常性眼眶病是一种具有水肿性和炎症性的疾病,通常为慢性,有时为亚急性或急性,多数病例的特征为眼球突出、眼睑退缩、伴有复视的限制性斜视、角膜溃疡、眼压升高以及压迫性视神经病变。眼球突出是主要体征。眼球突出多为轴性,85% - 90%的病例为双侧性。眼球在垂直和水平轴向上移位并不少见,尤其是当一条眼外肌强烈肿大产生占位效应时。眼球突出源于眶腔内空间的争夺。淋巴细胞、浆细胞和非常亲水的粘多糖对脂肪、肌肉和泪腺的浸润都促成了眼眶病。大多数轻度眼球突出的患者无需特殊治疗,因为他们往往会自行好转。在严重的情况下,评估使用类固醇的活性很重要,以消除软组织炎症,并在更好的条件下进行修复性手术。当未获得良好反应时,需评估放疗。对于静止型、毁容性眼球突出、某些特殊情况如甲状腺功能异常性视神经病变、眼压升高、角膜暴露等,可采用眼眶骨减压手术,有时还需行脂肪切除术。

相似文献

1
[Basedow exophthalmos].[巴泽多病性突眼]
J Fr Ophtalmol. 2009 Oct;32(8):589-99. doi: 10.1016/j.jfo.2009.09.001. Epub 2009 Oct 23.
2
[Orbital-bony decompression in patients with dysthyroid orbitopathy--first Croatian experiences].[甲状腺功能障碍性眼眶病患者的眼眶减压术——克罗地亚的首次经验]
Acta Med Croatica. 2006;60(2):83-6.
3
[Thyroid orbitopathy].[甲状腺眼眶病]
Harefuah. 2003 May;142(5):377-80, 396.
4
Rectus extraocular muscle paths and decompression surgery for Graves orbitopathy: mechanism of motility disturbances.甲状腺相关眼病的直肌眼外肌路径与减压手术:眼球运动障碍的机制
Invest Ophthalmol Vis Sci. 2002 Feb;43(2):300-7.
5
[Endocrine orbitopathy].[内分泌性眼眶病]
Praxis (Bern 1994). 2001 May 17;90(20):882-6.
6
Long-term follow-up and recent observations on 305 cases of orbital decompression for dysthyroid orbitopathy.305例甲状腺相关眼病眼眶减压术的长期随访及近期观察
Laryngoscope. 1989 Jan;99(1):35-40. doi: 10.1288/00005537-198901000-00008.
7
Diagnosis of exophthalmos using orbital ultrasonography and treatment of malignant exophthalmos with steroid therapy, orbital radiation therapy, and plasmapheresis.
Prog Clin Biol Res. 1983;116:189-205.
8
Thyroid orbitopathy.甲状腺眼病
Aust Fam Physician. 2003 Aug;32(8):615-20.
9
[Treatment of Grave's ophthalmopathy with high doses of corticosteroids].[大剂量皮质类固醇治疗格雷夫斯眼病]
Srp Arh Celok Lek. 2000 May-Jun;128(5-6):179-83.
10
[Is incidence of diplopia after Fat Removal Orbital Decompression a predictive factor of choice of surgical technique for Graves' ophthalmopathy?].[眼眶减压脂肪去除术后复视发生率是Graves眼病手术技术选择的预测因素吗?]
Bull Acad Natl Med. 2003;187(9):1649-58; discussion 1659-60.

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