Dubicanac Marko, Radespiel Ute, Zimmermann Elke
Institute of Zoology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany.
Primate Biol. 2017 Oct 27;4(2):215-228. doi: 10.5194/pb-4-215-2017. eCollection 2017.
Mouse lemurs, the world's smallest primates, inhabit forests in Madagascar. They are nocturnal, arboreal and dependent on vision for their everyday lives. In the last decades, the grey mouse lemur became increasingly important for biomedical research, in particular aging research. Experiments which require the combination of visual fitness and old age consequently depend on a solid knowledge of ocular pathologies. Although ocular diseases in mouse lemurs have been described as being common, they have not received much attention so far. Yet it is important to know when and why ocular diseases in captive mouse lemurs may occur. This review aims to provide a comprehensive overview of known ocular findings in mouse lemurs. It summarizes the frequency of ocular findings in captive mouse lemur colonies and points to their likely causes and treatment options based on the evidence available from other animals and humans. In addition, it shall be discussed whether age or genetic background may affect their development. This review may be used as a reference for future studies which require an assessment of visual performance in mouse lemurs and help to evaluate observed clinical signs and ocular diseases. Furthermore, the high incidence of specific diseases may provide new perspectives and set the groundwork for a new animal model for ocular research.
小鼠狐猴是世界上最小的灵长类动物，栖息在马达加斯加的森林中。它们是夜行性树栖动物，日常生活依赖视觉。在过去几十年里，灰小鼠狐猴在生物医学研究，尤其是衰老研究中变得越来越重要。因此，需要将视觉健康与老龄状态相结合的实验依赖于对眼部病理学的扎实了解。尽管小鼠狐猴的眼部疾病被描述为常见，但到目前为止它们并未受到太多关注。然而，了解圈养小鼠狐猴何时以及为何会出现眼部疾病很重要。这篇综述旨在全面概述小鼠狐猴已知的眼部发现。它总结了圈养小鼠狐猴群体中眼部发现的频率，并根据从其他动物和人类获得的证据指出其可能的原因和治疗选择。此外，还将讨论年龄或遗传背景是否可能影响它们的发展。这篇综述可作为未来研究的参考，这些研究需要评估小鼠狐猴的视觉表现，并有助于评估观察到的临床症状和眼部疾病。此外，特定疾病的高发病率可能提供新的视角，并为眼部研究的新动物模型奠定基础。
