Esterbauer H, Dieber-Rotheneder M, Striegl G, Waeg G
Institute of Biochemistry, University of Graz, Austria.
Am J Clin Nutr. 1991 Jan;53(1 Suppl):314S-321S. doi: 10.1093/ajcn/53.1.314S.
The fatty acid composition, antioxidants, and the oxidation resistance of the low-density lipoproteins (LDL) from a number of different donors were determined. The oxidation resistance of LDL, as determined in vitro by the duration of the lag-phase in copper ion-induced oxidation, did not correlate with the alpha-tocopherol content of the LDL. By supplementating plasma with vitamin E, the alpha-tocopherol content of LDL could be increased from approximately 9 to 30 mol/mol LDL and also the oxidative resistance increased nearly linearly with increasing alpha-tocopherol content. The results indicate that alpha-tocopherol is an important, yet not the only parameter that determines the oxidation resistance of LDL.
