US Army Institute of Surgical Research, Combat Wound Care, JBSA Ft. Sam Houston, San Antonio, Texas, USA.
Burn Center, US Army Institute of Surgical Research, Joint Trauma System, JBSA Ft. Sam Houston, San Antonio, Texas, USA.
J Burn Care Res. 2022 Nov 2;43(6):1260-1270. doi: 10.1093/jbcr/irac100.
Thermal burn injuries are still a serious public health concern in the United States, due to the initial insult and resulting comorbidities. Burned patients are increasingly susceptible to colonization by endogenous and exogenous microorganisms after having lost skin, which acts as the primary protective barrier to environmental contaminants. Furthermore, the onset of additional pathophysiologies, specifically sepsis, becomes more likely in burned patients compared to other injuries. Despite improvements in the early care of burn patients, infections, and sepsis, these pathophysiologies remain major causes of morbidity and mortality and warrant further investigation of potential therapies. Vitamin E may be one such therapy. We aimed to identify publications of studies that evaluated the effectiveness of vitamin E as it pertains to thermal burn injuries, infection, and sepsis. Several investigations ranging from in vitro bench work to clinical studies have examined the impact on, or influence of, vitamin E in vitro, in vivo, and in the clinical setting. To the benefit of subjects it has been shown that enteral or parenteral vitamin E supplementation can prevent, mitigate, and even reverse the effects of thermal burn injuries, infection, and sepsis. Therefore, a large-scale prospective observational study to assess the potential benefits of vitamin E supplementation in patients is warranted and could result in clinical care practice paradigm changes.
热烧伤在美国仍是一个严重的公共卫生问题，这是由于初始损伤和由此产生的合并症。烧伤患者在失去皮肤后，更容易被内源性和外源性微生物定植，而皮肤是抵御环境污染物的主要保护屏障。此外，与其他损伤相比，烧伤患者更容易发生其他病理生理变化，特别是脓毒症。尽管烧伤患者的早期治疗、感染和脓毒症有所改善，但这些病理生理变化仍然是发病率和死亡率的主要原因，需要进一步研究潜在的治疗方法。维生素 E 可能就是这样一种治疗方法。我们旨在确定评估维生素 E 对热烧伤、感染和脓毒症疗效的研究出版物。从体外实验室工作到临床研究的几项调查研究了维生素 E 在体外、体内和临床环境中的影响或影响。为了受试者的利益，已经表明肠内或肠外补充维生素 E 可以预防、减轻甚至逆转热烧伤、感染和脓毒症的影响。因此，有必要进行一项大规模的前瞻性观察性研究，以评估维生素 E 补充对患者的潜在益处，这可能会导致临床护理实践模式的改变。
