Molokhia Sarah A, Sant Himanshu, Simonis Jacquelyn, Bishop C J, Burr R M, Gale Bruce K, Ambati Balamurali K
Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA.
Vision Res. 2010 Mar 31;50(7):680-5. doi: 10.1016/j.visres.2009.10.013. Epub 2009 Oct 23.
Treatment of age-macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin was the drug of interest in this study. Prototypes were manufactured using polymethylmethacrylate sheets as the reservoir material, a semi-permeable membrane for controlled delivery and silicone check valves for refilling. The device showed near zero-order release kinetics and Avastin stability was investigated with accelerated temperature studies.
年龄相关性黄斑变性的治疗需要每月进行玻璃体内注射，这种治疗成本高昂且存在严重风险。本研究的目的是开发一种新型的眼内药物递送植入物。胶囊药物环是一种在白内障手术期间插入晶状体囊袋的储库，可再填充且能够递送多种药物。阿瓦斯汀是本研究中感兴趣的药物。使用聚甲基丙烯酸甲酯片材作为储库材料、用于控释的半透膜和用于再填充的硅胶止回阀制造了原型。该装置显示出接近零级的释放动力学，并通过加速温度研究对阿瓦斯汀的稳定性进行了研究。
