School of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya, East Java, 60115, Indonesia.
Drug Deliv Transl Res. 2022 Jun;12(6):1355-1375. doi: 10.1007/s13346-021-01043-z. Epub 2021 Aug 11.
The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal therapy requires injections that are administered frequently due to the rapid clearance of the drug molecules. As an alternative, intraocular implants can offer drug release for long-term therapy. However, one of the several challenges in developing intraocular implants is selecting an appropriate in vitro dissolution testing model. In order to determine the efficacy of ocular implants in drug release, multiple in vitro test models were emerging. While these in vitro models may be used to analyse drug release profiles, the findings may not predict in vivo retinal drug exposure as this is influenced by metabolic and physiological factors. This review considers various types of in vitro test methods used to test drug release of ocular implants. Importantly, it discusses the challenges and factors that must be considered in the development and testing of the implants in an in vitro setup.
将药物递送至眼部的后节仍然是一项极具挑战性的任务。由于药物分子的快速清除，传统的玻璃体内治疗需要频繁注射，从而延长了治疗时间。作为替代方法，眼内植入物可以提供长期治疗的药物释放。然而，开发眼内植入物的几个挑战之一是选择合适的体外溶解测试模型。为了确定眼内植入物在药物释放方面的疗效，出现了多种体外测试模型。虽然这些体外模型可用于分析药物释放曲线，但这些发现可能无法预测体内视网膜的药物暴露情况，因为这受到代谢和生理因素的影响。本综述考虑了用于测试眼内植入物药物释放的各种类型的体外测试方法。重要的是，它讨论了在体外环境中开发和测试植入物时必须考虑的挑战和因素。
