CHUQ Research Center, Québec, QC, Canada.
Neurotoxicology. 2010 Jan;31(1):17-25. doi: 10.1016/j.neuro.2009.10.008. Epub 2009 Oct 23.
Although lead (Pb) exposure has been identified as an important risk factor in child behavioral development, less is known regarding the relation between child behavior and exposure to polychlorinated biphenyls (PCBs) and mercury (Hg). Inuit children are particularly exposed to these chemicals and the aim of this study was to investigate the association between prenatal and postnatal exposure to Pb, PCBs, Hg and several aspects of behavioral function in Inuit preschoolers. The sample consisted of one hundred and ten 5-year-old Inuit children from Arctic Quebec. An umbilical cord blood sample was used to document prenatal exposure to Pb, PCBs and Hg. Child blood samples were collected at age 5 and the same contaminants were measured. A modified version of the Infant Behavior Rating Scale from the Bayley Scales of Infant Development-II was used to assess child behavior through examiners' ratings. Furthermore, attention, activity and emotional outcomes were assessed through behavioral coding of video recordings taken during fine motor testing. Pb exposure during childhood was associated with examiners ratings of greater impulsivity, irritability and with coding of observed inattention. Prenatal exposure to PCB 153 correlated with the examiners ratings of increased state of unhappiness and anxiety during the testing session, which was corroborated from video coding since cord PCB 153 was related to fewer manifestations of positive affects. No association was found with Hg exposure. These data corroborated those from previous Pb cohort studies and revealed an association between prenatal PCBs exposure and emotional outcomes in preschoolers.
虽然铅（Pb）暴露已被确定为儿童行为发育的重要危险因素，但对于儿童行为与多氯联苯（PCBs）和汞（Hg）暴露之间的关系知之甚少。因纽特儿童特别容易接触到这些化学物质，本研究的目的是调查因纽特学龄前儿童在产前和产后接触 Pb、PCBs、Hg 与行为功能几个方面之间的关联。该样本由来自北极魁北克的 110 名 5 岁因纽特儿童组成。脐带血样本用于记录产前接触 Pb、PCBs 和 Hg 的情况。在 5 岁时采集儿童血液样本，并测量相同的污染物。使用贝利婴幼儿发展量表第二版的婴儿行为评定量表的修改版通过评估员的评分来评估儿童行为。此外，通过精细运动测试期间的视频记录进行行为编码来评估注意力、活动和情绪结果。儿童时期的 Pb 暴露与评估者对冲动性、易怒性的评分以及对观察到的注意力不集中的编码有关。产前接触 PCB 153 与评估者在测试过程中增加不快乐和焦虑状态的评分相关，这从视频编码中得到证实，因为脐带 PCB 153 与较少的积极表现有关。与 Hg 暴露无关。这些数据与之前的 Pb 队列研究结果一致，并揭示了产前 PCBs 暴露与学龄前儿童情绪结果之间的关联。
