Centre for Arctic Health & Molecular Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Department of Ecoscience, Aarhus University, Roskilde, Denmark.
Int J Circumpolar Health. 2024 Dec;83(1):2381308. doi: 10.1080/22423982.2024.2381308. Epub 2024 Jul 30.
Humans are exposed to metals through diet and lifestyle e.g. smoking. Some metals are essential for physiologically body functions, while others are non-essential and can be toxic to humans. This study follows up on metal concentrations in the Greenlandic ACCEPT birth-cohort (mothers and fathers) and compares with other Arctic populations. The data from 2019 to 2020 include blood metal concentrations, lifestyle and food frequency questionnaires from 101 mothers and 76 fathers, 24-55 years, living in Nuuk, Sisimiut, and Ilulissat. A high percentage (25-45%) exceeded international guidance values for Hg. For the mothers, the metal concentrations changed significantly from inclusion at pregnancy to this follow-up 3-5 years after birth; some increased and others decreased. Most metals differed significantly between mothers and fathers, while few also differed between residential towns. Several metals correlated significantly with marine food intake and socio-economic factors, but the direction of the correlations varied. Traditional marine food intake was associated positively with Se, As and Hg. To the best of our knowledge, this study provides the most recent data on metal exposure of both men and women in Greenland, elucidating metal exposure sources among Arctic populations, and documents the need for continuing biomonitoring to follow the exceeding of guidance values for Hg. [Figure: see text].
人类通过饮食和生活方式（例如吸烟）接触金属。有些金属对身体的生理功能是必需的，而有些则是非必需的，对人类可能有毒。本研究跟踪了格陵兰 ACCEPT 出生队列（母亲和父亲）中的金属浓度，并与其他北极人群进行了比较。2019 年至 2020 年的数据包括 101 名母亲和 76 名 24-55 岁父亲的血液金属浓度、生活方式和食物频率调查问卷，他们居住在努克、西西缪特和伊卢利萨特。有 25-45%的人超过了汞的国际指导值。对于母亲来说，从怀孕到出生后 3-5 年的这次随访中，金属浓度发生了显著变化；有些增加了，有些减少了。大多数金属在母亲和父亲之间存在显著差异，而少数金属在居住城镇之间也存在差异。一些金属与海洋食物摄入量和社会经济因素显著相关，但相关方向不同。传统的海洋食物摄入量与硒、砷和汞呈正相关。就我们所知，本研究提供了格陵兰地区男女最近的金属暴露数据，阐明了北极人群的金属暴露来源，并记录了需要继续进行生物监测以跟踪汞指导值的超标情况。[图：见正文]。
