Department of Urology, Ajou University School of Medicine, Suwon, Korea.
Urology. 2010 Jan;75(1):138-42. doi: 10.1016/j.urology.2009.08.018. Epub 2009 Oct 24.
To identify the difference in autonomic nervous dysfunction activity in men between voiding symptom-predominant lower urinary tract symptoms (LUTS) and storage symptom-predominant LUTS.
A total of 39 men with LUTS (mean age 56.9 +/- 8.96 years) and 23 healthy men (mean age 57.0 +/- 1.76 years) were included in the present study. Seven questions numbered Q1 to Q7 in the order of appearance in International Prostate Symptom Score were divided into 2 clusters: one with Q1, Q3, Q5, and Q6 and the other with Q2, Q4, and Q7, representing voiding and storage symptoms, respectively. Patients were divided into either voiding symptom-predominant group, if mean voiding symptom score, defined as (Q1 + Q3 + Q5 + Q6)/4, is bigger than mean storage symptom score, defined as (Q2 +Q4 + Q7)/3, or storage symptom-predominant group otherwise. We measured and compared parameters of heart rate variability between men with LUTS and healthy normal subjects. We also compared heart rate variability of men between storage symptom-predominant LUTS and voiding symptom-predominant LUTS.
On frequency domain analysis, there was evidence of decreased high frequency (HF) in patients with LUTS (P <.05). In comparison of autonomic nervous dysfunction activity in LUTS patients, men with voiding symptom-predominant LUTS had relatively increased ratio of low frequency and HF than what was observed in men with storage symptom-predominant LUTS.
Patients with LUTS exhibited decreased HF indicated that they may have had some disease or imbalance in the autonomic nervous system, which may distinguish LUTS patients from healthy men. Also, patients with voiding symptom-predominant LUTS had relatively increased sympathetic activity than storage symptom-predominant LUTS patients.
识别排尿症状为主型下尿路症状（LUTS）和储尿症状为主型 LUTS 男性患者自主神经功能障碍活动的差异。
本研究共纳入 39 例 LUTS 男性患者（平均年龄 56.9 +/- 8.96 岁）和 23 例健康男性（平均年龄 57.0 +/- 1.76 岁）。国际前列腺症状评分（IPSS）中按出现顺序编号为 Q1 至 Q7 的 7 个问题分为 2 个簇：一个簇包括 Q1、Q3、Q5 和 Q6，另一个簇包括 Q2、Q4 和 Q7，分别代表排尿和储尿症状。如果平均排尿症状评分（定义为（Q1+Q3+Q5+Q6）/4）大于平均储尿症状评分（定义为（Q2+Q4+Q7）/3），则患者被分为排尿症状为主型组，否则为储尿症状为主型组。我们测量并比较了 LUTS 男性与健康正常男性之间心率变异性的参数。我们还比较了储尿症状为主型 LUTS 和排尿症状为主型 LUTS 男性之间心率变异性的差异。
在频域分析中，LUTS 患者的高频（HF）降低（P <.05）。与 LUTS 患者自主神经功能障碍活动的比较中，排尿症状为主型 LUTS 男性的低频和 HF 比值相对高于储尿症状为主型 LUTS 男性。
LUTS 患者 HF 降低表明他们可能患有某种疾病或自主神经系统失衡，这可能将 LUTS 患者与健康男性区分开来。此外，排尿症状为主型 LUTS 患者的交感神经活动相对高于储尿症状为主型 LUTS 患者。
