(D-吡喃葡萄糖基)-4-苯硫代缩氨基脲金属配合物的合成、结构、电化学和光谱特性及其对瑞士白化病小鼠艾氏腹水癌的抗肿瘤活性。
Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich ascites carcinoma in Swiss albino mice.
机构信息
Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580 003, Karnataka, India.
出版信息
Eur J Med Chem. 2010 Jan;45(1):106-13. doi: 10.1016/j.ejmech.2009.09.031. Epub 2009 Sep 28.
The novel glycosyl saccharide derivative, (D-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50=1.94 x 10(-8) (LC50=2.76 x 10(-8) for cisplatin) and so distinctly better than free ligand and other complexes.
新型糖基硫代缩氨基脲衍生物（D-吡喃葡萄糖-4-苯硫代）及其钴(II)、镍(II)、铜(II)和锌(II)配合物的合成、表征及细胞毒性作用研究。铜配合物[CuLCl]在 LC50=1.94 x 10(-8)（顺铂为 LC50=2.76 x 10(-8)）时，对瑞士白化病小鼠中的艾氏腹水癌细胞系具有显著的抑制作用，明显优于游离配体和其他配合物。
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