关于腹主动脉瘤的遗传问题。
On the inheritance of abdominal aortic aneurysm.
作者信息
Majumder P P, St Jean P L, Ferrell R E, Webster M W, Steed D L
机构信息
University of Pittsburgh.
出版信息
Am J Hum Genet. 1991 Jan;48(1):164-70.
Abstract
To determine the mode of inheritance of abdominal aortic aneurysm, data on first-degree relatives of 91 probands were collected. Results of segregation analysis performed on these data are reported. Many models, including nongenetic and genetic models, were compared using likelihood methods. The nongenetic model was rejected; statistically significant evidence in favor of a genetic model was found. Among the many genetic models compared, the most parsimonious genetic model was that susceptibility to abdominal aortic aneurysm is determined by a recessive gene at an autosomal diallelic major locus. A multifactorial component in addition to the major locus does not increase the likelihood of the data significantly.
摘要
为确定腹主动脉瘤的遗传模式，收集了91名先证者一级亲属的数据。报告了对这些数据进行分离分析的结果。使用似然法比较了许多模型，包括非遗传模型和遗传模型。非遗传模型被排除；发现了支持遗传模型的统计学显著证据。在比较的众多遗传模型中，最简约的遗传模型是腹主动脉瘤易感性由常染色体双等位基因主位点的隐性基因决定。除主位点外的多因素成分不会显著增加数据的似然性。
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