自身免疫中的调节性T细胞和抑制性细胞因子。
Regulatory T cells and inhibitory cytokines in autoimmunity.
作者信息
Bettini Maria, Vignali Dario A A
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Curr Opin Immunol. 2009 Dec;21(6):612-8. doi: 10.1016/j.coi.2009.09.011. Epub 2009 Oct 23.
Abstract
Foxp3(+) regulatory T cells (T(regs)) contribute significantly to the maintenance of peripheral tolerance, but they ultimately fail in autoimmune diseases. The events that lead to T(reg) failure in controlling autoreactive effector T cells (T(effs)) during autoimmunity are not completely understood. In this review, we discuss possible mechanisms for this subversion as they relate to type 1 diabetes (T1D) and multiple sclerosis (MS). Recent studies emphasize firstly, the role of inflammatory cytokines, such as IL-6, in inhibiting or subverting T(reg) function; secondly, the issue of T(reg) plasticity; thirdly, the possible resistance of autoimmune T cells to T(reg)-mediated control; and fourthly, T(reg)-associated inhibitory cytokines TGFbeta, IL-10 and IL-35 in facilitating T(reg) suppressive activity and promoting T(reg) generation. These recent advances place a large emphasis on the local tissue specific inflammatory environment as it relates to T(reg) function and disease development.
摘要
叉头框蛋白3（Foxp3）阳性调节性T细胞（Tregs）对维持外周免疫耐受起着重要作用，但在自身免疫性疾病中它们最终会失效。在自身免疫过程中，导致Tregs无法控制自身反应性效应T细胞（Teffs）的事件尚未完全明确。在这篇综述中，我们讨论了与1型糖尿病（T1D）和多发性硬化症（MS）相关的这种颠覆现象的可能机制。近期研究首先强调了炎性细胞因子（如IL-6）在抑制或颠覆Tregs功能中的作用；其次是Tregs可塑性问题；第三是自身免疫性T细胞对Tregs介导控制的可能抵抗；第四是与Tregs相关的抑制性细胞因子转化生长因子β（TGFβ）、白细胞介素-10（IL-10）和白细胞介素-35（IL-35）在促进Tregs抑制活性和促进Tregs生成方面的作用。这些最新进展高度强调了与Tregs功能和疾病发展相关的局部组织特异性炎症环境。
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