Departments of Anesthesiology and Pediatrics, University of Missouri, Columbia, Missouri 01199, USA.
J Intensive Care Med. 2009 Nov-Dec;24(6):361-71. doi: 10.1177/0885066609344836. Epub 2009 Oct 22.
The potent inhalational anesthetic agents are used on a daily basis to provide intraoperative anesthesia. Given their beneficial effects on airway tone and reactivity, they also have a role in the treatment of status asthmaticus that is refractory to standard therapy. Although generally not of clinical significance, these agents can affect various physiological functions. The potent inhalational anesthetic agents decrease mean arterial pressure and myocardial contractility. The decrease in mean arterial pressure reduces renal and hepatic blood flow. Secondary effects on end-organ function may result from the metabolism of these agents and the release of inorganic fluoride. The following article reviews the history of inhalational anesthesia, the physical structure of the inhalational anesthetic agents, their end-organ effects, reports of their use for the treatment of refractory status asthmaticus in the intensive care unit (ICU) patient, and special considerations for their administration in this setting including equipment for their delivery, scavenging, and monitoring.
强效吸入麻醉剂被广泛应用于日常的手术麻醉中。鉴于它们对气道张力和反应性的有益影响，它们在治疗对标准治疗无效的哮喘持续状态方面也有一定的作用。尽管这些药物通常没有临床意义，但它们可以影响各种生理功能。强效吸入麻醉剂会降低平均动脉压和心肌收缩力。平均动脉压的降低会减少肾和肝的血流。这些药物的代谢和无机氟化物的释放可能会对终末器官功能产生继发影响。本文回顾了吸入麻醉的历史、吸入麻醉剂的物理结构、它们对终末器官的影响，以及它们在 ICU 患者难治性哮喘持续状态治疗中的应用报告，并特别考虑了在这种情况下使用它们的注意事项，包括它们的输送、清除和监测设备。
