Novartis Vaccines and Diagnostics, Siena, Italy.
PLoS Genet. 2009 Oct;5(10):e1000612. doi: 10.1371/journal.pgen.1000612. Epub 2009 Oct 26.
It can be argued that the arrival of the "genomics era" has significantly shifted the paradigm of vaccine and therapeutics development from microbiological to sequence-based approaches. Genome sequences provide a previously unattainable route to investigate the mechanisms that underpin pathogenesis. Genomics, transcriptomics, metabolomics, structural genomics, proteomics, and immunomics are being exploited to perfect the identification of targets, to design new vaccines and drugs, and to predict their effects in patients. Furthermore, human genomics and related studies are providing insights into aspects of host biology that are important in infectious disease. This ever-growing body of genomic data and new genome-based approaches will play a critical role in the future to enable timely development of vaccines and therapeutics to control emerging infectious diseases.
可以说，“基因组时代”的到来，从根本上改变了疫苗和疗法开发的模式，使我们从基于微生物的方法转变为基于序列的方法。基因组序列为研究发病机制提供了以前无法实现的途径。基因组学、转录组学、代谢组学、结构基因组学、蛋白质组学和免疫基因组学正在被用于完善目标的识别，设计新的疫苗和药物，并预测它们在患者中的效果。此外，人类基因组学和相关研究正在为宿主生物学的各个方面提供重要的见解，这些方面在传染病中很重要。这些不断增长的基因组数据和新的基于基因组的方法，将在未来发挥关键作用，使我们能够及时开发疫苗和疗法来控制新发传染病。
