Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Am J Perinatol. 2010 Apr;27(4):321-4. doi: 10.1055/s-0029-1241732. Epub 2009 Oct 24.
We sought to determine the rate of adverse perinatal outcomes in pregnancies diagnosed with an isolated single umbilical artery (SUA). We performed a retrospective review comparing 68 pregnancies with an isolated SUA to 68 pregnancies with a three-vessel cord (3VC). Pregnancies with structural or karyotypic anomalies were excluded. Gestational age at delivery, birth weight, SGA rate, ponderal index, and rates of admission to the neonatal intensive care unit were compared between groups. Student T test and chi-square analysis were performed. Neonates with isolated SUA had a significantly smaller birth weight than those with a 3VC (3279 +/- 404 g versus 3423 +/- 374 g, P = 0.0168). There was no significant difference in rates of SGA (17.6% versus 8.8%, P = 0.06). Ponderal index was significantly less in those with SUA compared with 3VC (24.2 +/- 1.1 g/cm(3) versus 26.1 +/- 1.3 g/cm(3), P = 0.001). SUA neonates had a significantly longer length of neonatal intensive care unit stay than 3VC neonates (1.25 +/- 2.2 days versus 0.48 +/- 1.25 days, P < 0.023). Fetuses with a prenatal diagnosis of isolated umbilical artery have a significantly lower ponderal index compared with fetuses with a 3VC. Pregnancies with isolated SUA should undergo serial assessments for fetal growth.
我们旨在确定孤立性单脐动脉（SUA）妊娠的不良围产期结局发生率。我们进行了一项回顾性研究，比较了 68 例孤立性 SUA 妊娠和 68 例三血管脐带（3VC）妊娠。排除了结构或染色体异常的妊娠。比较两组之间的分娩时胎龄、出生体重、SGA 发生率、体质量指数和新生儿重症监护病房入院率。进行了学生 t 检验和卡方分析。孤立性 SUA 新生儿的出生体重明显小于 3VC 新生儿（3279±404 g 与 3423±374 g，P=0.0168）。SGA 发生率无显著差异（17.6%与 8.8%，P=0.06）。SUA 组的体质量指数明显低于 3VC 组（24.2±1.1 g/cm³与 26.1±1.3 g/cm³，P=0.001）。SUA 新生儿的新生儿重症监护病房住院时间明显长于 3VC 新生儿（1.25±2.2 天与 0.48±1.25 天，P<0.023）。产前诊断为孤立性脐动脉的胎儿体质量指数明显低于 3VC 胎儿。孤立性 SUA 妊娠应进行胎儿生长的系列评估。
