Cubo Ana María, Moreno Alicia, Sánchez-Barba Mercedes, Cabrero María Ángeles, Costas Tatiana, Rodríguez María O, Hernández Hernández María Estrella, Ordás Polán, Villalba Yarza Ana, Goenaga Francisco Javier, Lapresa-Alcalde María Victoria
Department of Obstetrics and Gynecology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain.
Faculty of Medicine, University of Salamanca (USAL), 37007 Salamanca, Spain.
J Clin Med. 2024 Dec 18;13(24):7749. doi: 10.3390/jcm13247749.
Single umbilical artery (SUA) is considered an ultrasound marker of anomalies. Although it may be present in about 0.5% to 6% of normal pregnancies, it has been linked with an increased risk of fetal growth restriction (FGR), as well as cardiac, genitourinary and gastrointestinal malformations and chromosomal anomalies such as trisomies 21 and 18. This study aims to evaluate whether the presence of isolated SUA (ISUA) is associated with adverse perinatal outcomes. A descriptive, observational and retrospective study was conducted, analyzing 1234 pregnancies (1157 normal gestations with a three-vessel cord and 77 cases of ISUA). ISUA was associated with a lower gestational age (38 vs. 39 weeks) and a lower birth weight (3013 vs. 3183 g) when performing a univariate analysis. However, after performing a multivariate analysis adjusted for maternal age and BMI, the association between single umbilical artery (SUA) and lower birth weight could not be proven. No significant differences were found in the rate of malformations, genetic disorders, Apgar score, pH at birth or admissions in the neonatal ICU. ISUA is associated with a lower birth weight but does not increase the risk of prematurity or low-birth-weight-related neonatal admissions. Additionally, ISUA is not significantly associated with a lower gestational age, genetic disorders, fetal malformations, worse Apgar scores or lower pH values at birth.
单脐动脉（SUA）被认为是一种异常的超声标志物。尽管它可能存在于约0.5%至6%的正常妊娠中，但它与胎儿生长受限（FGR）风险增加以及心脏、泌尿生殖系统和胃肠道畸形以及染色体异常（如21三体和18三体）有关。本研究旨在评估孤立性单脐动脉（ISUA）的存在是否与不良围产期结局相关。进行了一项描述性、观察性和回顾性研究，分析了1234例妊娠（1157例有三血管脐带的正常妊娠和77例ISUA病例）。在进行单因素分析时，ISUA与较低的孕周（38周对39周）和较低的出生体重（3013克对3183克）相关。然而，在对产妇年龄和BMI进行多因素分析后，单脐动脉（SUA）与较低出生体重之间的关联无法得到证实。在畸形率、遗传疾病、阿氏评分、出生时的pH值或新生儿重症监护病房的入院率方面未发现显著差异。ISUA与较低的出生体重相关，但不会增加早产风险或与低出生体重相关的新生儿入院风险。此外，ISUA与较低的孕周、遗传疾病、胎儿畸形、较差的阿氏评分或出生时较低的pH值无显著关联。
