乙型肝炎病毒感染

Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis.

机构信息

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

出版信息

J Med Virol. 2009 Dec;81(12):2079-88. doi: 10.1002/jmv.21638.

PMID:19856479

Abstract

Parvovirus B19 (B19V) has been detected in the liver of Asian patients infected with HBV and may contribute to acute and chronic liver disease. This study aimed to investigate the impact of B19V infection in European patients with viral hepatitis. B19V DNA was detected in 1/91 and 0/50 serum samples from patients with chronic hepatitis C and B, respectively. In contrast, B19V DNA was amplified frequently from explanted end-stage liver tissues (37/50, 74%) and from routine biopsy samples (14/32, 44%) (P < 0.05). However, there was no significant difference in B19V copy number per cell between these two groups. B19V-specific CD4(+) T-cell responses to two dominant MHC-class-restricted epitopes were detected in a similar frequency in healthy anti-B19V-positive individuals (3/19; 16%) and patients with chronic hepatitis C (3/13; 23%). These results indicate that B19V can persist in the liver. However, there is no evidence that B19V is a "hepatitis virus" worsening liver disease in European patients with chronic hepatitis C.

摘要

细小病毒 B19（B19V）已在感染乙型肝炎病毒的亚洲患者的肝脏中被检测到，可能导致急性和慢性肝病。本研究旨在调查 B19V 感染对欧洲病毒性肝炎患者的影响。慢性丙型肝炎和乙型肝炎患者的血清样本中，分别有 1/91 和 0/50 检测到 B19V DNA。相比之下，B19V DNA 经常从移植的终末期肝组织（37/50，74%）和常规活检样本（14/32，44%）中扩增（P<0.05）。然而，这两组之间每个细胞的 B19V 拷贝数没有显著差异。在慢性丙型肝炎患者中，健康抗 B19V 阳性个体（3/19；16%）和患者（3/13；23%）中均以相似的频率检测到针对两种主要 MHC 类受限表位的 B19V 特异性 CD4(+) T 细胞反应。这些结果表明 B19V 可以在肝脏中持续存在。然而，没有证据表明 B19V 是一种“肝炎病毒”，会加重欧洲慢性丙型肝炎患者的肝病。