[哈拉尔德·楚尔·豪森——一位充满激情的科学家。宫颈癌疫苗]

[Harald zur Hausen--a scientist with passion. Vaccine against cervical cancer].

作者信息

Długońska Henryka

机构信息

Załdad Immunoparazytologii, Katedra Immunologii i Biologii Infekcyjnej, Uniwersytet Łódzki, ul. Banacha 12/16, 90-237 Łódź.

出版信息

Wiad Parazytol. 2009;55(3):191-4.

PMID:19856833

Abstract

The profile of Harald zur Hausen, German virologist and Nobel-Prize winner for medicine in 2008, is presented in the context of his life and scientific achievements. The studies of zur Hausen on oncogenic viruses submitted a finding that chronic infection with certain highly invasive human papilloma viruses (HPV16 and HPV18 types) causes cervix carcinoma. The discovery was a starting point to successful construction of biosynthetic preventive vaccines against this carcinoma, such as "Gardasil" and "Cervarix".

摘要

本文介绍了德国病毒学家、2008年诺贝尔医学奖获得者哈拉尔德·楚尔·豪森的生平及科学成就。楚尔·豪森对致癌病毒的研究发现，某些具有高度侵袭性的人乳头瘤病毒（16型和18型HPV）的慢性感染会导致宫颈癌。这一发现成为成功构建针对该癌症的生物合成预防性疫苗（如“加德西”和“希瑞适”）的起点。